Simon Mwangi Kihu1*, George Chege Gitao1, Lily Caroline Bebora1, Njenga Munene John1, Gidraph Gachunga Wairire2, Ndichu Maingi1, Raphael Githaiga Wahome1, Davis Njuguna Karanja1, Julius Otieno Oyugi3, Ernest Lutomia3
...udy detail the clinical, pathological and laboratory findings of this outbreak. The disease was clinically manifested by the depression, diarrhea, difficult breathing, muco-purulent ocular-nasal discharges with matted eyelids and encrusted nostrils and finally death. Clinical outcome, gross lesions and histological observations were suggestive of PPRV infection, which were confirmed by the application of a reverse transcription–polymerase chain reaction ...
Chun-Yi Lin1, Meng-Ling Wu2, Tang-Long Shen1, Hsin-Hung Yeh3, Ting-Hsuan Hung1*
...ades ago without further pathological and genetic researches in Taiwan. Here, bioassay, multiplex RT-PCR and multiplex real-time RT-PCR were used to detect the current status of the two viroids showing HSVd was more prevalent than CEVd and simultaneous infections were common in field. Uneven distributions of both viroids also occurred in different tissues of citrus. Two multiplex molecular detection methods provide the understanding of the genetic diversities ...
Hu Zenglei1 and Xiufan Liu1, 2*
...erminants for the clinicopathological manifestations in infected hosts. Recent studies showed that the host innate immune responses to infection play important role in the pathologenesis of NDV, and correlate with the severity of the clinical disease. Virulent strains of different genotypes induce distinct pathological manifestations in chicken organs, especially in lymphoid tissues. Genotype VIId of NDV, which is currently ...
Shen Yang1, Guang-Zhi Tong1, 2*
...owever, HP-PRRSV induces pathological changes and can cause aberrant immune responses in the host, resulting in acute lung injury and immune dysfunction. Studies of the innate immune responses to HP-PRRSV infection are crucial to gaining insight into HP-PRRSV-induced pathogenesis and for the development of novel protective vaccines. In this review, we discuss the innate immune responses against HP-PRRSV infection and suggest new areas of investigation into thi...
Brittany D. Rife 1,2, Marco Salemi 1,2*
E-mail | salemi@pathology.ufl.edu
...uable insight into immunopathological processes, and ultimately paves the way for a better understanding of the interplay between viral evolution and pathogenesis....
Shubhada K Chothe, Bhushan M Jayarao and Suresh V Kuchipudi
...ethora of biological and pathological processes. There is a strong evidence to suggest the association of differential regulation of non-coding RNAs (ncRNAs) to a number of disease processes including viral infections. Cellular and virus encoded lncRNAs are emerging as novel regulatory factors which can escape the anti-protein environment in the virus infected cells and are likely to be conserved across the species. Here, we summarize our current knowledge abo...
Laila M. Fadda1, Nouf M. Al-Rasheed1, Iman H. Hasan1, Hanaa M. Ali2,3*, Nawal M. Al-Rasheed1,4, Musaed Al-Fayez5, Aly M. Ahmed5, Nada Almutlaq1, Nehal Qasem1 and Reem Khalaf1
...s were confirmed by histopathological examination using hemotoxylin and eosin (H&E) and Mason trichrome stains (MTC). Immunohistochemical investigations for the expression of the proapoptotic protein (Bax) and the expression of macrosialin cluster of differentiation (CD68). APAP elevated of most of the previously measured parameters and decreased GSH, SOD, and total protein levels. Liver sections of H&E demonstrated liver injury characterized by centri...
Mostafa A. Abdel-Maksoud1,2, Fathy A. Abdel-Ghaffar2, Azza El-Amir2, Gamal Badr3 and Saleh Al-Quraishy1*
...ion has resulted in histopathological changes and increased apoptotic cell death in splenic tissue of infected mice. Moreover, infection with live P. chabaudi was accompanied with an increase in NO, H2O2, and MDA levels in splenic tissue of lupus mice in comparison to either control or gamma irradiated P. chabaudi- infected group. Our data reveal that infection of lupus mice with live P. chabaudi has several effects on the splenic tissue on the histological an...
Shazia Irfan1*, Asima Rani1, Muhammad Arshad2 and Razia Bashir1
...ss is culprit of several pathological and physiological conditions. One of them is Rheumatoid arthritis (RA). The exact cause of RA is still unknown. Reduced activity of antioxidants enzymes because of polymorphisms in antioxidant genes and variations in levels of metals and minerals creates oxidative stress may play some role in progression and pathogenesis of RA. The objective of this study was to investigate the role of Superoxide dismutase 1 (SOD1) gene po...
Muhammad Luqman Sohail1,*, Muhammad Sarwar Khan1, Muhammad Ijaz1, Muhammad Avais1, Muhammad Yasir Zahoor2, Omer Naseer1 and Muhammad Usman Saleem3
Sadaf Ijaz Malik1, Kiran Afshan2* and Mazhar Qayyum1
... combined with examining pathological, hematological and bile biochemical response in buffaloes to Gigantocotyle explanatum infection. Of the 558 slaughtered buffaloes from central Punjab, Pakistan, 18.99% were infected, and morphometric analyses were made of 115 mature amphistomes and gravid eggs with traditional microscopic methods on the basis of standardized measurements. Amphistomes were flattened and stained in Borax carmine, some were sectioned i...
Hui Zhang2, Yajing Wang2, Kun Li2, Mujeeb Ur Rehman2, Fazul Nabi2, Rui Gui2, Yanfang Lan2 and Houqiang Luo1,2*
...firmed by necropsy, histopathological examinations and PCR analysis. The results showed, 20 chickens as positive for ALV-A (2.73%, 95% CI 1.7-4.2) and these chickens were found to be positive for ALV-A with the further distribution of 2.91% (95% CI 1.0-6.7), 3.70% (95% CI 1.5-7.5), 2.48% (95% CI 0.5-7.1), 3.13% (95% CI 0.6-8.9) and 1.30% (95% CI 0.2-4.6) in Anhui province of Huaibei, Suzhou, Bozhou, Bengbu and Fuyang, respectively. The present survey showed th...
Cansu Akbulut1,*, Tuğba Kotil2, Burcu Öztürk1 and Nazan Deniz Yön1
...ve investigated the histopathological effect on zebrafish ovaries after exposure to TiO2 nanoparticles. Adult zebrafish individuals were exposed to 1, 2 and 4 mg/L TiO2 for 5 days, and then their ovaries were evaluated using light and transmission electron microscopy. Numerous degenerated follicles with cytoplasmic vacuolization, mitotic catastrophe in mitochondria , chromatin condensation, mitochondrial vesiculation and dispersion at oop...
Abdul Aziz Khan1,*, Shahid Munir2 and Irfan Ahmed2
...e, external and internal pathological symptoms were similar as has been described for warfarin and brodifacoum. The bleeding period ranged from 8.06 to 12.94 nights with 13% variation in time. Based upon the total consumption of coumatetralyl bait, 400-450 wild boars were estimated as killed during the operation. The results of the study showed that coumatetralyl is a promising and potential alternate to sodium flouroacetate compound (1080) for managing wild b...
Yi-qiang Ouyang1, Zhen-xin Liang1, Shi-wen Huang2, Ying Zhang3, Shao-shi Luo1, Jin-ning Liang1, Jia-fu Li1, Yu He4 and Song-chao Guo1,*
Mustafa Cengiz1*, Jama Hussein Ali2, H. Mehtap Kutlu2, Djanan Vejselova2 and Adnan Ayhanci3
...D-GaIN, in terms of histopathological and biochemical values. In conclusion, EA might play an important role in repairing D-GaIN-induced liver damage both as a protective and a therapeutic agent.
...
Beenish Zahid1,*, Asim Aslam2, Zafar Iqbal Chaudhry2 and Raheela Akhtar2
...the biochemical and histopathological changes in response to pathogenic field infectious bursal disease virus (IBDV). The Bursa of fabricius was collected from poultry flocks of Punjab Pakistan for isolation of IBD virus by inoculating in embryonated chicken eggs through chorioallantoic membrane. The two hundred birds were divided into 4 groups A, B, C and D). The birds in group A were commercial broiler chicks having maternal derived antibodies and were chall...
Sanjukta Chakrabarti1, Colin J. Barrow2, Rupinder K. Kanwar3, Venkata Ramana1*, Rakesh N. Veedu4,5 and Jagat R. Kanwar3*
...ans, may lead to various pathological conditions including tumor development. The most important factor implicated in the angiogenic processes is vascular endothelial growth factor (VEGF) protein and its family of ligands and receptors (VEGFRs). Survival, proliferation, migration and invasion of endothelial cells which give rise to the vascular network, is mediated through VEGF/VEGFR activation of the signal transduction pathways. Thus blocking VEGF is an effi...
Gamalat Osman1, Mansour Galal1, Abbas Abul-Ezz2, Ahmad Mohammed1, Mohammed Abul-Ela3 and Asmaa Mostafa Hegazy2
...ing metabolism. The histopathological observations of the gills and mantle of L. carinatus showed pronounced alterations at 24 hours and proliferated at the day 15 but showed a further decline at the day 30 of exposure. These findings seem to be time related and were classified as reversible and irreversible changes. Accordingly, it can be concluded that L. carinatusis a typical bioindicator for crude oil pollution....
Saara Ahmad1,*, Iftikhar Ahmed2, Saida Haider3, Zehra Batool3, Fatima Ahmed4, Saiqa Tabassum3,6, Syeda Madiha3, Tahira Perveen3 and Saad Bilal Ahmed5
...lected, weighed and histopathologically evaluated for the development of cysts. It was seen that the ovaries of the group treated with caged chicken meat showed increased cholesterol levels, imbalanced steroidal sex hormone levels, increased ovary weight and development of the cysts upon histopathological examination as compared to the rats of other groups in the study.
...
Qamar-un-Nisa1, Muhammad Younus2,*, Muti-ur-Rehman1, Azhar Maqbool3 and Sajid Umar4
Fatma Abdallah1*, Ola Hassnain2, Elsayed Attar3, Haytham Ali3,5, Mohamed Megahed1 and Venugopal Nair4
Souheila Slimani1,*, Sonia Hamouda1, Chahrazed Souadi1, Sara Silini2, Cherif Abdennour2 and Leila Delimi3
... semen quality, and histopathological profile were investigated at week 10.The obtained results reveal that under a long photoperiodthe sexual activity of the control lasted only 04 weeks, characterized by significant increase in the testicular volume, followed by spontaneous gonadal regressionup to week 10. Consequently, an azospermia and lack of germ cells in control birds was noticed,which confirm the testicular regression.In the treated groups, thiram dela...
Jam Nazeer Ahmad1,2,*, Rashid Mushtaq1, Samina Jam Nazeer Ahmad1,2, Sumaira Maqsood3, Ishita Ahuja4 and Atle M. Bones4
Wajid Ali1,*, Asma Karim1, Muhammad Irfan2, Hafiz Abdullah Shakir3*, Ghulam Mustafa4, Zeeshan Shafique1, Ijaz Anwar1
...tein was decreased. Histopathological result reveled that gills of experimental fish was damage severely resulting Necrosis, Damaged nuclei , rupturing of epithelial cells, Mucous cells and severe lamellar fusion. It was concluded that, deltamethrine is highly toxic for non-target aquatic organisms like silver carp (Hypophthalmicthyes molitrix).
...
Tahir Abbas*1, Khawaja Raees Ahmad2, Asmatullah3, Khalid Pervaiz Lone4, Muhammad Ali Kanwal2, Sadia Suleman2
Reno-hepatic protective effects of Jambul against chromium induced anomalies in mice
...for biochemical and histopathological analysis.Cr+6 treated group showed severe histological changes like necrosis, cirrhosis and dehydration in liver evident by significant elevation of Serum Glutamic Pyruvic Transaminase (SGPT), Serum Glutamic Oxaloacetic Transaminase (SGOT), Alkaline Phosphatase (ALP), total protein, bilirubin, globulin, creatine and uric acid along with reduction of SGOT/SGPT, Blood Urea Nitrogen (BUN), urea and albumin as compared to cont...
Ihsan Ali1#, Asim Aslam1*, Habib-ur-Rehman2, Beenish Zahid3, Ishtiaq Ahmed1
Effect of fish oil on growth performance and immune response in experimentally infected broiler chicken with avian influenza virus H9N2
...
were the prominent histopathological changes observed in challenged group. It is
concluded that fish oil improve the growth performance and immune response in
broilers chicken against avian influenza virus infection....
concluded that fish oil improve the growth performance and immune response in
broilers chicken against avian influenza virus infection....
Hina Abrar1,2, S.N.H. Naqvi1,*, Muhammad Rashid Ahmed3, Asma Basharat Ali3 and Hina Yasin1,2
...pranolol group. The histopathological examination reveals various features of hepatic architecture damage in CBZ treated group but the hepatic damage induced by CBZ was successfully ameliorated by propranolol. To conclude propranolol is effective in reducing the hepatoxic effects of CBZ probably by affecting hepatic blood flow.
...
Muhammad Kashif Maan1, Ghulam Mustafa1, Munibullah2 and Sajid Umar2,*
...on the clinical and histopathological examination of the tumor sample. In all cases, tumor resection was performed followed by cauterization of the remaining surface with silver nitrate. No postoperative complications or local recurrence were reported by owner of each case.
...
Farheen Shaikh*, Saima Naz, Nadir Ali Birmani
...different biological and pathological problems. Chewing lice have a high capability to develop host specificity. In present study the chewing lice (Phthiraptera: Insecta) were examined for their population and rate of infestation on Common quail Coturnix coturnix (Aves: Galliformes: Phasianidae) from Jamshoro and Hyderabad Districts, Sindh, Pakistan. The study was conducted during 2013-2014. Twenty-six Common Quails were observed in four localities incl...
Mehwish Akram1,2,* and Naeem Rashid1
... Kir channels related to pathological conditions and diseases.
... 
