Histopathological Analysis of the Male White Mice Liver After Exposure to Halothane Anesthesia
Histopathological Analysis of the Male White Mice Liver After Exposure to Halothane Anesthesia
Duaa Jasim Mohammad
ABSTRACT
In order to assess the histopathological changes in the liver of mice post-anesthesia, a total of 40 male white mice were divided into three groups (n=10/group). Three groups of mice were administered halothane with increasing concentration (1%, 2% and 3%) and the control group was left untreated. Each group was given halothane for 15 minutes every day for 30 consecutive days. A through histopathological analysis of the liver of treated group (1% halothane) revealed parenchymal degradation, cystic dilatation filled with blood, granuloma, lipid accumulations, and inflammatory cell aggregation. After exposure to a 2% and 3% concentration of halothane, tissue sections of the liver revealed extensive aggregation of Kupffer’s cells, granuloma, lipidosis, bile buildup, and extremely broad sinusoidal dilatation in different parts of the liver parenchyma, as well as a high number of inflammatory cells present around the affected hepatocytes. In contrast, liver of the untreated control group depicted normal histological features. Findings of this study articulate that halothane anesthesia can induce pathology in the liver of male white mice and offer consideration of mice as animal model to investigate useability, practicalities and implication of such anesthetic agents in animal health practices.
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