Impact of Empagliflozin on the Kidneys of Male Albino Rats
Impact of Empagliflozin on the Kidneys of Male Albino Rats
Amal Mahmood Alwan1*, Thekra Atta Ibrahim1, Ghalib Idrees Atiya Ali2
ABSTRACT
This study aims to investigate the effect of empagliflozin in Albino rat animal model. The drug is previously known to impact the histological structure of the kidneys of male rats, however, mechanistic insights remained unknown. To investigate generic impact of the drug in animals, 15 adult male rats were randomly divided into two groups. The control group consisted of 5 rats, while the treatment group was divided into two subgroups, each consisting of 5 rats. Diabetes condition was induced in all animals of treatment sub-groups with alloxan with 5 mg/kg concentration of empagliflozin, once daily for 30 days- and the animals of the first sub-group were left untreated. A through examinations showed pathological and histological changes in the group of animals with induced diabetes without treatment, as well as in the group with diabetes and treated with empagliflozin. These lesions were characterized by the intra-glomerular haemorrhage and infiltration of inflammatory cells. It was also noted that there was damage to the epithelial lining of some renal tubules, and separation of the cells lining the tubules and their accumulation in the middle of the renal tubule in most sections. In addition, some sections showed glomerular enlargement, while in other sections it shrank, in addition to cell death inside it and the appearance of narrowing of the lumen of some urinary tubules. Accordingly, empagliflozin has clear effects on the histological structure of the kidneys of male rats with induced diabetes. Taken together, our results highlight the importance of using animal model to address wider health issue and propose the consideration of animals in understanding future molecular mechanisms of diseases.
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