Adverse Histo-Physiological Damages of Increasing Consummation of Puma (Super Fat) on Female Rats
Adverse Histo-Physiological Damages of Increasing Consummation of Puma (Super Fat) on Female Rats
Fatima Aziz Mahdi Al-Badry
ABSTRACT
The using of nutritional supplements is an issue reflected on human health because its intake randomly, Puma (super fat) is a one of nutritional supplements which used for weight increasing. So, the aim of the present study was to estimate dangerous effects of Puma (super fat) on kidney and liver functions and histopathological alterations of these organs. The total number of animals in present experiment was thirty two of adult female rats, It were divided into two groups (16/each), the first group which gave distilled water as control group while the second group was divided into three subgroups (A, B and C) which treated with nutritional supplement Puma (super fat) at (250 mg/kg body weight) for three periods (one, two and three months), respectively. The dose of Puma was given for rats by gavage. At the end of experiment period for each group, blood was collected and serum obtained in purpose of chemical examinations were included functions of kidney as (urea and creatinine) and liver enzymes (ALT, AST and ALP). After that, all rats were dissected then kidney and liver were eradicated for histopathological examinations. The results indicated to puma administration led to significant increase (P≤0.05) in urea and creatinine concentrations with significant decrease (P≤0.05) in ALT, AST and ALP these changes in functions of kidney and liver enzymes were elevated by increasing consumption of Puma (super fat). Histological sections of studied organs were manifested lesions in tissues by receiving of puma, it involved many histopathological changes (mild, middle and very severe injuries) in renal structure as hemorrhage, congestion, inflammation and structural disorders such as breakdown, death and absence of glomeruli with increasing of Bowman’s space. while these histological changes in liver were included congestion, hemorrhage, hypertrophy as well as necrosis of the hepatocytes. Conclusion: It was concluded in this study eating of Puma for long times causes renal-hepatic damages.
Keywords | Puma, (Super fat), Histopathological changes, Urea, Liver enzymes, Rats, Nutritional supplements, Biochemical indices, Traditional products
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July 2024
Vol. 12, Iss. 7, pp. 1206-1409
