Pathological Effects of Candida Auris Yeast on Liver of White Male Mice Pre-Treated with Alcoholic Extract of Syzygium Aromaticum
Pathological Effects of Candida Auris Yeast on Liver of White Male Mice Pre-Treated with Alcoholic Extract of Syzygium Aromaticum
Anas A. Humadi1*, Samer I. Sabeeh2, Ahmed Talib Yassen Aldossary3, Bushra I. Al-Kaisei2
ABSTRACT
Candida auris (C. auris) is a yeast which is mainly identified in gastrointestinal, skin, mucous membrane and female genital tract. The Syzygium aromaticum (cloves) are extensively being used as food preservative and carry therapeutic, cosmetic and agricultural application. In order to understand the impact of Syzygium aromaticum against C. auris, 30 white male mice (aged 2-3 month and 35-40 gram of bodyweight were divided into 3 groups. The first group (n=10) acted as untreated control group; the second group of mice (n=10) received a single intraperitoneal administration of 2x 108 cell of C. auris. In another group of 10 mice, animals were subjected to a single intraperitoneal of 2x108 cell of candida auris followed by 1000 mg/kg alcoholic extract orally of Syzygium aromaticum for 90 days. Blood samples were collected from heart for assay catalase enzyme activity and lymphocyte count at 90 days of experiment whereas tissue sample from liver were taken for pathological examination. Comprehensive analysis of the biochemical analysis indicated a decrease in catalase enzyme and lymphocyte count in C. auris treated groups. Pathological changes were characterized by fibrosis, necrosis, hemorrhage, infiltration of inflammatory cells and liver cirrhosis in C. auris treated group compared to Syzygium aromaticum treated and C. auris infection mice. Taken together, it is clearly attributed that alcoholic extract of Syzygium aromaticum protect liver damage against C. auris potentially by increasing in catalase enzyme and lymphocyte count in treated mice.
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