Bee Venom for the Treatment of Rabbit Arthritis Caused by Staphylococcus aureus
Bee Venom for the Treatment of Rabbit Arthritis Caused by Staphylococcus aureus
Heba S.S. Salem1, Hend M. Megahed2, Marwa M. Sarhan2, Maha M. El Alem3, Gehan N. Alagmy3*
ABSTRACT
This study was taken to assess the effect of administration of bee venom alone or added to systemic antibiotics for curing septic arthritis caused by Staphylococcus aureus (S. aureus). Thirsty-five naturally infected cases of rabbits with arthritis were screened for the prevalence of S. aureus as a causative agent. S. aureus was diagnosed in 40% of the examined cases via traditional culture methods and molecular confirmation using PCR. All tested S. aureus isolates were positive for virulence-associated genes (nuc, icaA, and Hlg). In an experimental trial, a total of 75 healthy rabbits were divided equally into five groups (n =15/each group). The first group served as a negative control, the second group was injected intra-articulately with S. aureus, did not receive any treatment, and served as a positive control group, the third group received a subcutaneous injection of bee venom (BV), the fourth group was injected intra-articulately with S. aureus and treated with a subcutaneous injection of BV, the fifth group was injected intra-articulately with S. aureus and treated with a subcutaneous injection of BV and gentamicin. On the 7th and 14th days, post-infection animals were examined for hematological, biochemical, and histopathological assessments. The obtained results revealed that S.aureus infection caused marked alterations in hematological and biochemical parameters compared to the negative control, while treatment with BV alone or combined with gentamicin revealed a significant improvement of these parameters. Likely, treatment with BV caused an improvement in the histopathology compared with the untreated groups. In conclusion, BV treatment is of value in the treatment of S. aureus-induced arthritis in rabbits.
Keywords | Antibacterial Activity; Bee Venom; Staphylococcus aureus; Septic Arthritis
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