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Atrazine Induced Histopathological Alterations in the Liver of Adult Male Mice

Atrazine Induced Histopathological Alterations in the Liver of Adult Male Mice

Sajida Batool1, Saira Batool1, Sitara Shameem1, Fatima Khalid1, Tahira Batool2, Summera Yasmeen1, Saima Batool3*

1Department of Zoology, University of Sargodha, Sargodha, Pakistan
2Department of Chemistry, University of Sargodha, Sargodha, Pakistan
3Institute for Advanced Study, Shenzhen University, Shenzhen, China.
 
Corresponding Author: Saima Batool
saimabatool118@gmail.com

ABSTRACT

Atrazine is a commonly used triazine derived herbicide that is a major pollutant of soil and water and highly carcinogenic. To investigate Atrazine induced pathological changes in the liver of albino laboratory mice, 20 adult male mice were equally distributed (n=10) into two groups. Atrazine was given at the dose of 200 mg/kg body weight through gavages for 28 days while the control (Cnt) group remains untreated. On the 29th day, all animals were sacrificed to recover liver for histological preparations. Atrazine (ATZ) caused various hepatic implications in the treated animals. ATZ exposure caused a significant decline in mean body and liver weight as compared to the Cnt group. The histopathological findings in ATZ administered group included loosening hepatic tissue, massive degeneration of hepatocytes, deformed nuclei of hepatocytes, highly disordered trabecular arrangement, vacuolar degeneration, diffuse necrosis, congestion and degeneration of the hepatic portal vein. Micrometric data indicated a significant reduction in themean number of hepatocytes and oval cells per unit area in ATZ treated group as well as significantly increased size and nuclear diameter of hepatocytes compared to the Cnt group. These findings showed the sensitivity of all cell types in the liver to the toxic potentials of atrazine at the given dose level.
 
Novelty Statement | This study reports hepato-toxic effects of atrazine at a particular dose level which has not been reported before. 
 

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Pakistan Journal of Zoology

December

Vol. 53, Iss. 6, Pages 2001-2521

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