Ameliorative Pathological Aspect of Pumpkin Seed Oil and Rousovastatin on Lipid Profile and Glucose Level in Rats
Ameliorative Pathological Aspect of Pumpkin Seed Oil and Rousovastatin on Lipid Profile and Glucose Level in Rats
Abbas A. Khudhair1*, Mohammed A. Qathee2, Muhsin S.G. Almozie’l3, Kassim F. Abdulkarem4
ABSTRACT
Dyslipidemia is a condition characterized by an abnormal cholesterol and triglyceride metabolism. Here we aim to evaluate pumpkin and rousovastatin for their effect on lipid profile and glucose level in laboratory rats. For this purpose, thirty female rats were used after induction of hyperlipidemia through cholesterol administration, divided in to five groups and treated with different concentrations of pumpkin and rousovastatin. Pumpkin group (treated with 200mg/kg), rousovastatin group (treated with 20mg/kg) and comb group (treated with 20mg/kg rousovastatin and 200mg/kg pumpkin seed oil). Pumpkin and rousovastatin groups showed a significant decrease (p<0.05) in total cholesterol, triglyceride, LDL-C, VLDL-C and glucose level, while there is a significant increase (p<0.05) in HDL-C when compared to positive control. However, rousovastatin caused a significant increase (p<0.05) in AST, ALT and creatinine level when compared to control group. Histopathological examination reveals varying degrees of fatty degeneration, vascular congestion along with infiltration of inflammatory cells in comparison to pumpkin and negative control. Renal tissue showed atrophy of some glomeruli along with infiltration of inflammatory cell with tubular degeneration in rosuovastatin group, while pumpkin group is similar to normal control kidney tissue. Taken together, pumpkin seed oil offers a protective effect by lowering lipid and glucose concentration. In addition to hypolipidemic effect of rousovastatin, it affected glucose level positively but should be used with a lower dose to avoid their adverse effect on biochemical parameters.
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