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Intra-Host Bayesian Phylogeography Linking Viral Evolution and Pathogenesis Comes to an Age

Intra-Host Bayesian Phylogeography Linking Viral Evolution and Pathogenesis Comes to an Age

Brittany D. Rife 1,2, Marco Salemi 1,2*

E-mail | salemi@pathology.ufl.edu

1Department of Pathology, Immunology, and Laboratory Medicine; 2Emerging Pathogens Institute, University of Florida,
Gainesville, FL 32610, USA.

ABSTRACT

Bayesian phylogeographic analysis has recently been at the forefront of understanding epidemiological processes through the reconstruction of evolutionary history and spatial dissemination of pathogens. Infection of a single host can be viewed similarly as an epidemic spread on a microscale, creating a unique opportunity for the application of phylogeography at the intra-host level, which has until recently been limited by dataset quality and the lack of a rigorous statistical framework. As recently described in studies using the SIV-macaque model of neuroAIDS, the incorporation of
spatial, temporal, and demographic inference into intra-host evolutionary analysis using Bayesian phylogeography allows for inference of pathogen migration between infected tissues and cell types, provides valuable insight into immunopathological processes, and ultimately paves the way for a better understanding of the interplay between viral evolution and pathogenesis.

 

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Hosts and Viruses

December

Vol. 7, Iss. 6, Pages 129-146

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