Intra-Host Bayesian Phylogeography Linking Viral Evolution and Pathogenesis Comes to an Age
Intra-Host Bayesian Phylogeography Linking Viral Evolution and Pathogenesis Comes to an Age
Brittany D. Rife 1,2, Marco Salemi 1,2*
E-mail | salemi@pathology.ufl.edu
ABSTRACT
Bayesian phylogeographic analysis has recently been at the forefront of understanding epidemiological processes through the reconstruction of evolutionary history and spatial dissemination of pathogens. Infection of a single host can be viewed similarly as an epidemic spread on a microscale, creating a unique opportunity for the application of phylogeography at the intra-host level, which has until recently been limited by dataset quality and the lack of a rigorous statistical framework. As recently described in studies using the SIV-macaque model of neuroAIDS, the incorporation of
spatial, temporal, and demographic inference into intra-host evolutionary analysis using Bayesian phylogeography allows for inference of pathogen migration between infected tissues and cell types, provides valuable insight into immunopathological processes, and ultimately paves the way for a better understanding of the interplay between viral evolution and pathogenesis.
To share on other social networks, click on any share button. What are these?
