Ameliorating Effect of Linseed Oil Against Fluconazole Induced Adverse Effect on Male Fertility of Cocks
Ameliorating Effect of Linseed Oil Against Fluconazole Induced Adverse Effect on Male Fertility of Cocks
Nour El-Hoda Khayrat Hammad1*, Yousef Y. El-Seady3, Azza E. Hassan1, Sara T. Elazab2, Magdy S. Amer2
ABSTRACT
This study was designed to investigate the modulating effects of linseed (LIN) oil on some fertility alterations induced by fluconazole (FCZ) in cocks. Thirty White Leghorn cocks were used and divided into three groups (ten in each). The 1st group was served as control, the 2nd group received FCZ (5 mg/kg body weight (BW)/day for 7 days) in drinking water, while the 3rd group received FCZ in drinking water for a week, then given LIN oil (60 ml/kg basal diet) for two weeks. FCZ administrated cocks showed elevation in abnormal sperm % and significant decrease in serum testosterone hormonal levels and spermatozoa (viability and motility) which accompanied by some histopathological damage in testes and epididymis. On a molecular basis, mRNA expression of CYP17A1 and LHR genes were significantly reduced in testicular tissues of FCZ group while aromatase gene was elevated. The administration of LIN oil after FCZ treatment markedly improved the aforementioned alterations caused by FCZ. So linseed oil is capable to ameliorate the fluconazole induced fertility disorders.
Keywords | Male fertility, Antifungal, Medicinal plant, Testosterone hormone, Aromatase
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