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Microencapsulated Symbiotic and Phytosteroids to Enhance Reproductive pattern in Male Albino Rats

Microencapsulated Symbiotic and Phytosteroids to Enhance Reproductive pattern in Male Albino Rats

Emtenan M. Hanafi1*, Fouad M. Tawfeek2, Walid S. El Nattat1, Moetazza M. Alshafei3, Seham S. Kassem3, Kawkab A. Ahmed4, Enas N. Danial5, Hagar Elbakry3, Hoda S. El-Sayed2

1Department of Animal Reproduction and AI, NRC, Dokki, Giza, Egypt; 2Department of Dairy Science, NRC, Dokki, Giza, Egypt; 3Department of Nutrition and Food Science, NRC, Dokki, Giza, Egypt; 4Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt; 5Department of Chemistry of Natural and Microbial Products, NRC, Dokki, Giza, Egypt.

*Correspondence | Emtenan M. Hanafi, Department of Animal Reproduction and AI, NRC, Dokki, Giza, Egypt; Email:


Obesity affects metabolic hormones and consequently the male fertility. spirulina platensis (SP) and Bifidobacterium longum (BL) were known as health potentiators. The aim of this study was to produce microcapsules to act as functional feed additives to enhance general health and to study its effect on the reproductive performance of male albino rat. Total flavonoids, total phenolics, DPPH, HPLC and antimicrobial test against different types of bacteria were done for SP extract. BL has been microencapsulated in association with SP. Twentiy eight. adult male rats were divided into 4 equal groups. G1 received high fat diet (HFD), G2 received HFD and microencapsulated BL, G3 was supplemented by HFD plus encapsulated SP and BL. While G4 received basic diet as a control. After 2 months, animals were sacrificed. Results showed that SP had antimicrobial effect against pathogenic bacteria while, it kept probiotic bacteria alive. The animals fed on HFD showed elevated lipid profile, leptin, oxidative markers and low level of testosterone and the epididymal Spermatozoa had low sperm viability and higher abnormalities than control group. Feeding the microcapsules (G2,G3) improved the animals’ health condition. Animals in G2 showed good spermatozoa profile while, those fed SP (G3) showed low sperm count and motility. Histopathological examination declared testicular degeneration in G1 and G3 and a high spermatogenesis in G2 compared to control group. It was concluded that spirulina may act as health potentiator but also, may negatively affect the male reproductive performance. Special care should be paid for the dose and frequency of administration of any polyphenol or health potentioators.
Keywords | Spirulina platensis, Bifidbacterium longum, Spermatozoa profile, Male fertility

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Advances in Animal and Veterinary Sciences


Vol. 12, Iss. 8, pp. 1410-1621


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