The Role of Plant Complex Sterility Agent in Rats via FAM209 Regulating PICK1
The Role of Plant Complex Sterility Agent in Rats via FAM209 Regulating PICK1
Chun Shi*, Ziyu Cao, Mingyuan Yang and Meijing Zhai
ABSTRACT
This animal study aimed to investigate the regulatory effect of FAM209, and PICK1protein in SD rats with Rodent pest. SD rats are randomly divided into control group, low (10 mg/kg of plant complex sterility agent) and high dose (20 mg/kg of plant complex sterility agent) groups. Hematoxylin and eosin staining is used to observe the pathological changes of testis tissue. The testis organ index, male seminal vesicle, and sperm were also detected. The expression of FAM209, and PICK1protein in testis tissue are detected by Western blotting. Compared with the control group, the cell structure in the testis tissue of the model group is damaged, and testis organ index, male seminal vesicle, the sperm density level in the control group, low dose group are significantly increased (P<0.05). The results of WB confirm the expression of FAM209 (P<0.05). downregulated of FAM209, and PICK1protein may be involved in the development of rodent pest.
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