Comparative Effects of Phyllanthus niruri and Plantago major in Carbon Tetrachloride Intoxicated Rats
Comparative Effects of Phyllanthus niruri and Plantago major in Carbon Tetrachloride Intoxicated Rats
Asmaa Khamis1, Osama Abdalla1, Mohamed Hashem2, Noha Abdelnaeim1*
ABSTRACT
Liver damage is recognized as a severe global health issue. Phyllanthus niruri (PN) and Plantago major (PM) are herbal plants that are supposed to have hepatoprotective properties. This study aimed to compare the effects of both medicinal plant extracts on rats intoxicated with carbon tetrachloride (CCl4). A total of 60 male albino rats were equally distributed in six groups. The first group received purified water and was kept as a control. The second and third groups were given oral PN and PM (500 mg/kg/day) for 31 days, respectively. The fourth group was intraperitoneally injected with CCl4 (2 ml/kg/day) on days 15 and 16 of the experiment. The fifth and sixth groups received oral PN and PM (500 mg/kg/day), respectively, for 31 days and were injected with CCl4 on days 15 and 16. On days 17 and 32 of the trial, liver specimens were gathered for estimation of malondialdehyde (MDA), antioxidants, apoptotic markers, cytokines, and histopathological changes. Our results revealed a significantly increased MDA, caspase-3, p53, tumor necrosis factor-α, interleukin (IL)-1β, IL-18 and, IL-10, and a significant decline in glutathione and superoxide dismutase in the CCl4 group. However, intoxicated groups treated with PN and PM showed marked improvement in the measured parameters. Therefore, PN and PM have antioxidant and anti-inflammatory effects, especially PM, which showed better improvement than PN against CCl4 hepatotoxicity in rats.
Keywords | Phyllanthus niruri, Plantago major, carbon tetrachloride, hepatotoxicity, histopathology, apoptotic markers
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July 2022
Vol. 10, Iss. 7, Pages 1423-1658
