The Therapeutic Effect of Coriander Aquous Extract and Garlic Juice Against Experimentally Infested Goats with Haemonchus contortus
The Therapeutic Effect of Coriander Aquous Extract and Garlic Juice Against Experimentally Infested Goats with Haemonchus contortus
Al-Hassan M. Mostafa1*, Gehan Mohammed Sayed2
ABSTRACT
In this study the therapeutic effect of garlic juice and coriander extract against experimental infection of Haemonchus contortus (H. contortus) in goat was evaluated. Goats were divided into 4 groups; the 1st one represented control negative (clinically normal). All animals of other groups were infected via stomach tube with 1750 of 3rd stage larvae of H. contortus (L3) and subsequently subdivided into positive infected untreated group (second group), positive infected and orally treated group with garlic juice, 5ml/ animal, (third group) and positive infected and orally treated group with coriander extract, 0.9g/ Kg b.w. (fourth group). Fecal samples were collected weekly after 3 weeks post infection for Fecal Egg Count (FEC). One animal of each group was slaughtered at 7th week of experiment for sampling of abomasal specimens for histopathological examination and tissue estimation of Total peroxide, malondialdehyde (MDA), protein carbonyl (PC), Catalase, reduced glutathione (GSH) and superoxide dismutase (SOD). Garlic and coriander treated goats showed significant reduction of FEC as compared with control positive ones. Treated goats exhibit no changes in total peroxides while there were non significant changes of PC, MDA, Catalase and SOD, in contrast there was an obvious increase of GSH. Histopathologically, Abomasum tissue restored completely normal histological features in Garlic treated goats, however the abomasum was partially restored to the normal histological feature in coriander treated goats. In conclusion, the high flavonoid and phenol content of A. sativum ingredients have the ability to repair the degenerative hazards induced in a goat infested by Haemonchus contortus which aid in healing process. However, the time that Coriandrum sativum needs for repairing affected tissue is relatively more than that of Allium sativum.
Keywords | Goat, Haemonchus contortus, Garlic, Coriander and abomasum.
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