Optimizing Bone Healing in Rabbit Models: A Comparative Study of Lidocaine Hydrochloride and Diclofenac: Histological Study
Optimizing Bone Healing in Rabbit Models: A Comparative Study of Lidocaine Hydrochloride and Diclofenac: Histological Study
Qamer J. Jadoaa, Raffal A. Omar*
ABSTRACT
The present study aimed to evaluate the effect of intraosseous injection rout of 2% lidocaine hydrochloride and 3.75% Diclofenac, on bone regeneration. Forty-five adult male rabbits of the local breed were employed to create a 3.5mm hole defect in the proximal third of the medial aspect of the tibia by an electric drill with dropping isotonic normal saline to prevent thermal necrosis. The experimental animals were divided randomly into three equal groups, each group include fifteen rabbits (n=15). control without any additive. group 1(lidocaine hcl). Which applied daily single dose of 2% lidocaine Hcl 2 mg/Kg. B. W. for five days post-operation (P. O.), while the group 2(diclofenac) applied 3.75% of 20mg/Kg. B. W. histopathological specimens were taken at the end of the 7th,14th, and 21th day p.o. The results revealed rapid bone regeneration improvement and development in group I compared to group II and control group. In conclusion, intra-osseous injection of 2% Lidocaine Hcl 2mg/kg BW (body weight) has a stimulatory effect on bone healing in which osteogenic tissue and trabecular bone were noticed clearly at the end of 1st week, which achieves histologically compared to Diclofenac and control groups.
Keywords | Lidocaine hydrochloride, Diclofenac, Bone healing, Histological analysis, Intraosseous injection
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March 2024
Vol. 12, Iss. 3, pp. 392-585
