Effect of Chitosan on Induced Skin Wound Healing in Rabbits: Histopathological Evaluation
Effect of Chitosan on Induced Skin Wound Healing in Rabbits: Histopathological Evaluation
Falah Mahmood Hameed1*, Asaad Khalaf Talal AL-Shuwaili2, Eman Jawad Jabber3, Mayada Sahib Hassan1
ABSTRACT
The objective of the current study was to assess how chitosan affects the capacity of rabbits to heal full-thickness cutaneous lesions, 24 clinically healthy adult male rabbits weighing 1.5 to 2 kg were utilized in the experiment. The interplay between intramuscular of 5 mg/kg xylazine hydrochloride, 35 mg/kg ketamine hydrochloride, and 1 mg/kg diazepam were carried out. Based on the sort of treatment applied, these animals were allocated into three groups (A, B, and C). Chitosan powder was applied locally to wounds in group (A), as well as administered orally in group (B), and the wounds were left untreated in group (C) as a standard group. Each group was split into four subgroups, each consisting of two wounds, for histological analysis at the 0, 3, 7, and 14-day post-wound production and treatment durations. The findings showed that the speed of wound healing in treated rabbits were faster than non-treated rabbits. Additionally, the findings showed that treated groups had improved cellularity and expanded angiogenesis compared to non-treated group. Conclusion: The histological results supported the hypothesis that chitosan enhances and promotes the development of wound healing on the skin.
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