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Cholangiocarcinoma with Multiple Organ Metastasis in a Captive Puma (Puma concolor)

Cholangiocarcinoma with Multiple Organ Metastasis in a Captive Puma (Puma concolor)

Ho-Seong Cho1 and Yeonsu Oh2,*

1College of Veterinary Medicine and Bio-Safety Research Institute, Jeonbuk National University, Iksan 54596, Republic of Korea
2Department of Veterinary Pathology, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Republic of Korea

*     Corresponding author:


A 17-year-old captive male puma (Puma concolor) died after presenting anorexia, vomiting, weight loss and lethargy. At necropsy, the right middle lobe of the liver was severely affected by a tumor, and small tumor nodules were disseminated throughout the other lobes. The numerous tumor nodules were also found in the lung, stomach, kidney, heart and diaphragm, which were growing together, suspiciously metastatic, projecting, 5 to 40 mm in diameter and tawny to white in color. Histopathologically, the tumor was composed of prominent papillary-acinar structures and the cells had a resemblance to the biliary epithelium. Immunohistochemically, the tumor cells were strongly reactive for cytokeratin and CD10 and were negative for carcinoembryonic antigen, fetoprotein and hepatocyte paraffin-1. Taken together, the tumor was diagnosed as cholangiocarcinoma. This is the first case report of a cholangiocarcinoma in the puma.

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Pakistan Journal of Zoology


Vol. 54, Iss. 1, Pages 1-501


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