Effects of Naringenin on Cadmium-Induced Changes in Blood Physiological and Biochemical Indices and Kidney Damage Among Rats
Effects of Naringenin on Cadmium-Induced Changes in Blood Physiological and Biochemical Indices and Kidney Damage Among Rats
Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Mengli Jiang and Jicang Wang*
ABSTRACT
In this experiment, the effects of naringenin (Nar) on cadmium (Cd)-induced changes in blood physiological and biochemical indices and kidney damage among rats were studied. Twenty-four male Sprague–Dawley rats were randomly divided into four groups: control group, Cd-treated group (1 mg/kg b.w. CdCl2), Nar-treated group (100 mg/kg b.w.), and Cd + Nar-treated group (1 mg/kg b.w. CdCl2 + 100 mg/kg b.w. Nar). They were treated for 4 weeks, and then the blood physiological and biochemical indicators were assessed. The levels of glutathione (GSH), malondialdehyde (MDA), catalase (CAT), and total superoxide dismutase (T-SOD) were measured. Histopathological sections of the kidney were made to observe the structural damage. Results showed that the red blood cell count (RBC), hemoglobinconcentration (HGB), and hematocrit(HCT) of serum were significantly reduced after Cd exposure for 4 weeks. Cd increased the expression of GSH and MDA and decreased the activities of CAT and T-SOD. Furthermore, in the Cd-treated rats, the glomerulus contracted, the renal tubular structure was damaged, the epithelial cells were disordered and degenerated, and a large area of lesions occurred. However, treatment with Nar slowed down the occurrence of oxidative stress induced by Cd. Therefore, as an effective antioxidant, Nar has a certain protective effect on oxidative stress and kidney injury induced by Cd.
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