Preventive Role of Propolis and L-Arginine ® Supplement on Dna Damage for Sperm and Male Reproductive Hormones Values in Selenium Nanoparticles-Remedied Rats
Preventive Role of Propolis and L-Arginine ® Supplement on Dna Damage for Sperm and Male Reproductive Hormones Values in Selenium Nanoparticles-Remedied Rats
Zainab Sattar Ali* , Safa Azhar Razzaq , Layla Hammody Hashem
ABSTRACT
Rapid growth of uses of selenium nanoparticles (SeNPs) in our environment made the evaluation of its toxicity an urgent requirement. This study designed to investigate the impact of Green synthesized of SeNps and prophylactic effects of L-Arginine and propolis for male reproductive system. The animals evenly partitioned to four groups; (G1) group: were received distilled water. (G2) group: were intubated 200mg/kg B.W of Black Tea Selenium Nanoparticles (BTSe), (G3) group: were intubated 200 mg/kg of (BTSe) + 200 mg/kg of L-Arginine, (G4) group: were intubated 200 mg/kg of BTSe+ 200 mg/kg of propolis. The samples of blood had gathered from rats each three weeks for assessed the concentration value of FSH, LH, testosterone, and inhibin B hormone for each of groups above. At the termination of experiment were taken in from them specimen of testes for a purpose pathohistology study and assessed the percentage of DNA fragmentation. The current study observed damage in this sperms DNA and alteration of histopathological section. In addition reduction the levels of testosterone, inhibin b, FSH and LH hormones in group that ingestion BTSeNPs comparing the remnant groups, also been noted this reduction in above hormones getting worse with time progresses of experimental. In group4 show the propolis was enhancer factor for adverse effect of BTSe where FSH, LH, testosterone and inhibin b hormones values are elevated than remnant groups, as well as elevated the percentage integrity sperm DNA comparing with remnant groups. Concluded, the current experience revealed SeNPs have oxidative stress on reproductive system at high concentration, as well as the propolis and L-Arginine and has prophylactic effects on testes against the effect of SeNPs, regarded to his the antioxidant impact.
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