Ameliorative Effect of GSPE Against AFB1 Induced Immunotoxicity and Hepatotoxicity in Japanese Quail
Ameliorative Effect of GSPE Against AFB1 Induced Immunotoxicity and Hepatotoxicity in Japanese Quail
Maha Khalil1, Gamal Shams2, Hosny Abdel Fadil2, Nagah Edrees2, Mostafa Abonorag1, Nasser El-Sabbagh3, Eman A. Ahmed4*
ABSTRACT
This study was conducted to assess the ability of grape seed proanthocyanidin extract (GSPE) to alleviate the detrimental effects triggered by aflatoxin B1 in Japanese quail. Four groups of Japanese quail birds were fed either a basal diet (control), basal + 1mg/kg AFB1 (AFB1 diet), basal+ 500 mg/kg GSPE (GSPE diet), or basal+ 1mg/kg AFB1+ 500 mg/kg GSPE (AFB1+GSPE diet) for 5 weeks. Biochemical parameters, lipid peroxidation, pro-inflammatory cytokines, and histopathological investigations were assessed. GSPE supplementation alleviated AFB1-induced hepatotoxicity as reflected in diminishing alanine transaminase, aspartate aminotransferase, alkaline phosphatase, lipid peroxidation, and raising TNF-α and IL-6 as pro-inflammatory cytokines. Moreover, elevating the reduced levels of glutathione peroxidase, catalase, and superoxide dismutase were reported. Conclusively, the results of our experiment suggest that that GSPE is a good feed additive for alleviating the negative impacts induced by aflatoxin B1.
Keywords | Aflatoxin B1, Hepatotoxicity, Liver apoptosis, Proanthocyanidin, Quails
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April 2022
Vol. 10, Iss. 4, Pages 712-954
