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Zinc in Alkaline Water (Zamzam) Ameliorates Doxorubicin induced Cardiac Remodeling

Zinc in Alkaline Water (Zamzam) Ameliorates Doxorubicin induced Cardiac Remodeling

Mohammed A. Almujtaba1, Turky Omar Asar2, Salma Naqvi3, Vikas Kumar4, Fahad A. Al-Abbasi1, Abdulbasit I. Al-Sieni1 and Firoz Anwar1*

1Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. 
2Department of Biology, College of Science and Arts, University of Jeddah, Jeddah, Kingdom of Saudi Arabia 
3Department of Biomedical Sciences, Gulf Medical University, Ajman, United Arab Emirates 
4Natural Product Discovery Laboratory, Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences. SHUATS, Naini, Prayagraj, India
 
* Corresponding author: fanwar1@kau.edu.sa

ABSTRACT

The holy Zamzam water is believed to be beneficial in curing several diseases. Studies report that its alkaline nature renders it a therapeutic potential. We aimed to determine the effect of Zamzam water in doxorubicin induced cardiac remodeling in rats. Male Wistar albino rats were divided into 4 groups (n=6) for 28 days of experimental protocol. Group-1 served as normal control (NC), group 2 as doxorubicin control (DC), group 3 as doxorubicin+ Zamzam treatment (DZ) and group 4 as Zamzam control (ZZ). Doxorubicin (1mg/ kg bw) was injected i.p. in DC and DZ groups on first day of study. NC and DC groups were at normal bottled water p.o., while DZ and ZZ groups received Zamzam water p.o. for 28 days. At the end of protocol, the animals were sacrificed, heart preserved, and blood collected for biochemical estimations. Serum levels of cardiac biomarkers, CRP, Fibrinogen, BUN and creatinine increased, while zinc, IL-10 and angiotensin levels decreased significantly in DC as compared to NC. Interestingly, renin level also decreased in DC group. Heart tissues from each group were examined for histological changes. Altered serum levels of the biomarkers were restored on treatment with Zamzam water. Histopathological studies are in agreement with cardioprotective influence of Zamzam in cardiac dysfunction. Research findings endorse the cardioprotective potential of Zamzam in doxorubicin induced cardiac remodeling. We attributed this effect to the presence of zinc in alkaline medium of Zamzam.

 

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Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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