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Effect of Aloe Vera Extract on Some Parameter Complete Blood Count and Liver Functions Induced by Azathioprine in Changes Male Rats

Effect of Aloe Vera Extract on Some Parameter Complete Blood Count and Liver Functions Induced by Azathioprine in Changes Male Rats

Ahmed Al-Hasnawi*, Wafaa Kadhim Jasim

Physiology, Pharmacology and Biochemistry Department, Veterinary Medicine College, University of Kerbala, Karbala, Iraq.

 
*Correspondence | Ahmed Al-Hasnawi, Physiology, Pharmacology and Biochemistry Department, Veterinary Medicine College, University of Kerbala, Karbala, Iraq; Email: ahmdalhsnawy817@gmail.com

ABSTRACT

As azathioprine’s usage in our environment grew quickly, it became important to assess their toxicity, The goal of the current investigation was to determine if aloe vera extract had any protective effects against the hematological and histopathological alterations brought on by azathioprine. animals are evenly divided into four categories: (G1) group: were received distilled water. (G2) group: were administrating azathioprine (50mg/kg. b. w). (G3) group: were administrating Aloevera gel extract (500mg/kg b.w). (G4) group: were administrating azathioprine (50mg/kg. b. w) and aloe vera gel extract (500mg/kg b.w). after four weeks, blood samples from the rats were taken to measure MCV, MCH, MCHC, GST, GSH, and MDA levels. a liver sample was also taken for each of the aforementioned groups to be examined histopathological. According to the findings, azathioprine dramatically decreased the MCV, MCH, and MCHC blood test results as compared to the control group receiving only regular aloe vera, as well as the levels of the function liver enzymes GST and GSH. In contrast to the control group, azathioprine treatment led to a considerable rise in MDA levels when liver function enzymes were measured, but aloe vera administration caused them to revert to normal levels. aside from the liver’s histological alterations brought on by the administration of azathioprine, there were also impacts and enhancements brought on by the use of the aloe vera extract. Based on the results, the current study came to the conclusion that the liver damage brought on by immunosuppressive drugs such azathioprine differs from the positive results attained by giving male rats (aloe vera extract) and lowering the toxicity.
 
Keywords | Azathioprine, Aloe vera, Hematological, Liver’s function enzymes, Histopathological, Male rats

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Advances in Animal and Veterinary Sciences

June

Vol. 12, Iss. 6, pp. 994-1205

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