Immune-Pathological Studies on the Distribution and Localization of Bovine Viral Diarrhea Virus
Immune-Pathological Studies on the Distribution and Localization of Bovine Viral Diarrhea Virus
Mahmoud S. Sirag1*, Effat L. El Sayed2, Mahmoud M. Hussein3, Khalid A. El-Nesr1, Mahmoud B. El-Begawey1
ABSTRACT
Bovine viral diarrhea virus (BVDV) causes major economic losses in farms as a result of reproductive disorders and immunosuppression. To identify the pathological alterations and Immunohistochemical localization and distribution of BVDV antigen in the genital organs of persistently infected and acutely infected cows, this study was carried out on genital organs of thirty cows submitted to slaughter houses suffering from reproductive disorders. Pathologically, three mummified fetuses had been extracted from the uterus of examined cows (3/30). The disrupted growing and mature follicles were a distinctive microscopic feature in infected animals while such changes were absent in negative cows. The intact oocytes were clearly pronounced only in the negative animals. The fallopian tubes are free from any pathological lesions in the negative animals. Immunohistochemical, BVDV antigen was detected in ear notch, ovaries, fallopian tubes and uterus of one cow (1/30) (PI animal). Whereas, BVDV antigen was detected only in the genital organs of acutely infected animals (2/30) but ear notch was negative. The positive BVDV antigen was clearly observed in the PI cow in the ovaries (primordial, growing, follicles, follicular fluid, granulosa cells, ovarian stroma and blood vessels), the fallopian tube (covering epithelium, sub mucosa and musculosa) and at the uterus (epithelium, endometrial glands, blood vessels and endometrial stroma). While in the acute cases, the positive BVDV antigen could not be observed in the primordial follicles, blood vessels or endometrial glands.
Keywords | Bovine Viral Diarrhea Virus, Immunohistochemistry, Ovaries, Oviducts, PI cow, Uteri
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