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Effect of Total Phenolic Acid on the Repeated Cerebral Ischemia-Reperfusion Model in Mice

Effect of Total Phenolic Acid on the Repeated Cerebral Ischemia-Reperfusion Model in Mice

Mingsan Miao*, Hui Zhao, Jiaojiao Jia, Xiaoyan Fang and Yanyan Miao

College of Postgraduates, Henan University of Chinese Medicine, Zhengzhou 450046, China

*      Corresponding author:



This study aim to investigate the effects of total phenolic acid on the neuronal enolase and brain biochemical factors in the cerebral ischemia-reperfusion mice model and to assess the protection mechanism of cerebral ischemia-reperfusion injury. The repeated cerebral ischemia-reperfusion mice model was used where bilateral common carotid artery was targeted to block blood flow, reperfusion and then re-blocking the arteries. Brain tissues were examined 24 hours post-drug administration to determine the level of biochemical indicators such as serum NSE in the brain tissue. To investigate the impact of total phenolic acid on the biochemical parameters in the repeated cerebral ischemia-reperfusion mice, the mouse model of cerebral ischemia repeated reperfusion was successfully replicated. The doses of total phenolic acid of D. canes have significantly reduced the levels of IL-6 and TNF-α in brain tissue and decreased the level of NSE in the serum.Collectively, it was observed that the total phenolic acid can protect the brain tissue by inhibiting the expression of inflammatory factors, repairing damaged nerve cells and improving the pathological changes of cerebral ischemia, proposing its therapeutic potential in treating such anomalies in future. 

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Pakistan Journal of Zoology


Pakistan J. Zool., Vol. 56, Iss. 2, pp. 503-1000


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