Aradhana Chopra1, Ravi Shukla2 and Tarun Kumar Sharma2,3*
...cs, biomarker discovery, drug delivery, bio-imaging and molecular therapy. In this review we have summarized recent advancements and applications of aptamers in biology....
Josef D. Jarhult1, 2
...ns of the anti-influenza drug oseltamivir (Tamiflu®) have been intensely debated lately. This article aims to sum up what is known about positive and negative effects of the drug. The available data suggests that oseltamivir treatment of uncomplicated influenza in otherwise healthy patients shortens influenza symptoms with approximately 24 hours, and increases nausea and vomiting by 3-5%. Whether oseltamivir treatment ha...
Muhammad Arif Zafar1*, Arfan Yousaf1, Murtaz-ul-Hasan1, Faisal Ayub Kiayani1, Matee ul Islam2 and Muhammad Farooq Iqbal1
...roidal anti-inflammatory drug, good outcome in the calf was obtained. There was no postoperative complication suggesting that modified two-layer hand-sewn anastomosis technique was a successful technique. It was concluded that traumatic hernia may lead to septic shock and modified two-layer hand-sewn anastomosis technique may be recommended in calves with no postoperative complications and there is a good chance for long-term survival....
Behzad Hussain1, 2, Abdullah Iqbal2, Muhammad Abubakar2*
... but Ribavirin antiviral drug is used to cure this disease. There is currently no commercially available vaccine for this disease. It is recommended that the disease can be controlled by adopting preventive measures such as avoiding of tick bites and contact with blood of the suspected animal. ...
Muhammad Ibrahim, Jawaria Ali Khan, Muhammad Sarwar Khan, Wasim Shehzad, Muhammad Avais, Ali Husnain, Naimatullah Khan, Muhammad Kamran Ameen and Abdullah Iqbal
... were the most efficient drugs as 66% cows suffering from subclinical mastitis were recovered by treatment of each of them. Cows suffering from subclinical mastitis showed a 50 % recovery percentage when treated with lemon for five days and 33 percent cows recovered from subclinical mastitis when treated with Black Pepper for five days. Udder health status and milk quality can be enhanced with use of Garlic and Vitamin E + Se combination in cows....
Shagufta Jabeen1, Muhammad Saqlain Raja1, Sadia Saeed1, Muhammad Mobeen Zafar1, Rizwana Abdul Ghani1, Abid Mahmood1, Muhammad Fiaz2, Pakeeza Arzoo Shiaq1, Shahid Mahmood Baig3, S.M. Saqlan Naqvi1 and Ghazala Kaukab Raja1*
... including other illicit drugs is a chronic, relapsing multifactorial disorder of brain and, if left untreated, major medical, social, and economic problems arise. Drug addiction is among major health issues faced by the World including Pakistan with an alarming annual increase in heroin addicts. The study was designed to identify the socio-demographic risk factors contributing to increasing susceptibility to heroin addictio...
Atul Sharma, Aruna Chandra Singh, Gautam Bacher, Sunil Bhand
...he consequences of multi drug resistance and potential threat to human health and the environment. With the increasing incidences of antimicrobial contamination, especially in food, dairy products, agriculture and environment, their regular monitoring is on prime interest. Aptamers are synthetic short sequences of single stranded (ss) oligonucleotides (ss-RNA or DNA), which are developed by an in-vitro selection process known as “Systematic Evolution of ...
Taghreed A. Hafiz1, Murad A. Mubaraki1*, Mohamed A. Dkhil2,3 and Saleh Al-Quraishy2
...ombination with standard drug to treat herpes infection....
Ecevit Eyduran1, Daniel Zaborski2*, Abdul Waheed3, Senol Celik4, Koksal Karadas5 and Wilhelm Grzesiak2
...on standards, favourable drug doses and required feed amount for animals. The ascertainment of the body measurements associated with BW using data mining algorithms can be considered as an indirect selection criterion for future goat breeding studies. ...
KM Fakhrul-Islam, Mohammad Shah Jalal, Sonnet Poddr, Md Nurul Quader, Md Sahidur-Rahman, Avijit Dutta and Shuvo Mazumder
...ering clinical signs and drugs used for treatment during 13 January to 15 March 2015. A total of 131 cattle was investigated and 16.8% cattle cattle were recorded as FMD. The proportionate prevalence of FMD in different study areas were 4.5-18.2%. The occurrence of FMD was higher in February (23.3%) than in January (13.5%) and March (18.5%). Younger cattle were more commonly affected (59.1%) than older ones. Almost 96% of the female cattle were FMD positive. C...
Tuli Dey, Sonnet Poddar and Mukti Barua
...ihistaminic and hormonal drugs were given. This case as well as the condition of the animal were followed up and gave the result of successful recovery without any complication....
Eman M. Farghaly1, Ahmed Samy1,2*, Heba Roshdy
...rmation is important for drug choice and success of treatment as well as spotting the light on emerging antimicrobial resistance that represent major concern for public health. A total one hundred swabs and 500 organ samples were collected from apparently healthy and freshly dead quails respectively. Bacterial isolation and characterization were performed in accordance with the clinical laboratory standards and confirmed by PCR. In life birds, only E.coli and ...
Salman Khalid1,*, Abdul Rehman2, Mohammad Yasin Amir1, Abdul Rehman1, Imran Sarfaraz1 and Muhammad Asif1
...nd efficacy of different drugs on controlling tick’s infestation in commercial layer, a double blind randomized controlled trial was conducted. For therapeutic trials, the 80 birds (n= 60 infested with ticks, n= 20 healthy birds) were selected and divided into four groups (A, B, C and D), each comprising of 20 birds. Group A and B were treated with Ivermectin @ 0.2mg/Kg orally for two days and Fipronil (Spray at once), respectively. Group C was kept as p...
D. C. Khatua, B. Mondal and G. Saha
Bioassay of some agricultural chemicals, human drugs and disinfectants on Phytophthora melonis Katsura causing fruit and vine rot of pointed gourd
...ctants and antiprotozoal drugs were tested on Phtophthora melonis Katsura causing fruit and vine rot of pointed gourd in aqueous environment. Antifungal antibiotics viz. validamycin, kasugamycin, griseofulvin, fluconazole and ketoconazole did not have any pronounced effect on mycelial growth, sporangia formation and its germination. None of the eight antibiotics used in this study prevented mycelial growth. No sporangia formation was recorded in five antibioti...
Saba Irshad1,*, Ayesha Ashfaq1, Ammara Muazzam1 and Abida Yasmeen2
...onsiderably cheap herbal drug which can be prescribed to poor people efficiently at an affordable cost.
...
Usman Waheed1,*, Humayoon Shafique Satti2, Muhammad Arshad3, Ahmed Farooq3, Abdul Rauf4 and Hasan Abbas Zaheer1,5
...oners and 48 intravenous drug users (IDUs) through community outreach, peer referring and field sampling. Blood samples were tested for syphilis and HIV infections after pre-test counseling and receiving informed written consent. Initial testing was performed by rapid devices approved by World Health Organization (WHO) and confirmed by Chemiluminescence Immunoassays (CLIA). Of total 387 respondents, 149 subjects tested positive for syphilis (38.5%), whereas 37...
Jawad Anwar* and Zafar Iqbal
...ial source of antibiotic drugs as it showed a wide range of bioactivity against both phyto and human pathogenic bacteria. ...
Fang Wang, Yong-Fang Jia, Po Wang, Qi-Yan Du and Zhong-Jie Chang*
...is a triazole-containing drug that can inhibit the activity of cytochrome P450 aromatase, so as to affect the production of estrogen. In the present study, to detect the effects of letrozole on gonad differentiation, 5dph fry of carp were exposed to different concentrations of LET. At 130 dph, sex ratio was recorded. The results showed that continuous exposure to LET induced the changes of sex ratio. High concentration of LET can promote male-biased sex ratio....
Alaeldein M. Abudabos1,*, Abdullah H. Alyemni2, Elsayeid O. Swilam1 and Mu’ath Q. Al-Ghadi3
...o standard anticoccidial drug (Elancoban) in experimentally induced coccidiosis in broiler. A total 200 birds (Ross 308) were randomly assigned to 10 treatments on day 15 after introduction of coccidiosis. The results indicated that feed intake and production efficiency factor (PEF) did not differ significantly (P>0.05) between Elancoban and natural products. However, treatment had a significant effect on BWG and FCR (P<0.01 and P<0.001, respectively)...
Muhammad Usman Qamar1, 2, Sidrah Saleem1, Usman Arshad1, Muhammad Farhan Rasheed3, Hasan Ejaz4, Naveed Shahzad5 and Shah Jahan6,*
...ved to be most effective drug. Manuka honey manifested significant antibacterial activity against all test isolates with almost similar zone of inhibition (7.4mm) except E. cloacae. Highest MIC and MBC of manuka honey was observed against K. pneumoniae (30%v/v) while lowest against A. baumannii (20%v/v). Here, we conclude that Manuka honey possess potent antibacterial activity and might be used as an alternative treatment option against ND...
Sanjukta Chakrabarti1, Colin J. Barrow2, Rupinder K. Kanwar3, Venkata Ramana1*, Rakesh N. Veedu4,5 and Jagat R. Kanwar3*
...nesis. Several anti-VEGF drugs have been developed over the last two decades and some are still at different development stages of pre-clinical and clinical trials. In this study, we explored the anti-angiogenic properties of three anti-VEGF molecules such as two fusion proteins, VEGF TrapR1R2 and VEGFR1(D1-D3)-Fc, and one DNA aptamer, RNV66, in an in vivo model of human A549 lung cancer. VEGF TrapR1R2 is a commercial anti-angiogenic fusion protein. Our earlie...
Tahira Perveen1,*, Shaista Emad1, Saara Ahmad2, Zehra Batool1, Sarwat Yousuf1, Sheeza Sheikh1, Sara Qadeer1 and Saida Haider1
...epressants are effective drugs for the treatment of psychiatric disorders. Along with the effectiveness these drugs are also associated with some side effects. Since ancient times herbs are used as medicinal purposes. One such herb is Fennel (Foeniculum vulgare). Fennel has many efficacious uses. It is a common herb and spice. It is used in many culinary purposes and also it has therapeutic purposes. In the present st...
Sana Imran1*, Sarwat Jahan2 and Mohammad Sair3
...ic patients taking these drugs.In this randomized and comparative study, psoriasis severity was checked by Psoriasis Area Severity Index (PASI). At day 90 Calcipotriol treated group B patients showed more improvement in mean PASI score as compared to Betamethasone valerate treated group A patients. In PASI score, Calcipotriol shows 71.61% betterment whereas Betamethasone vale rate shows 63.2% betterment in mild psoriatic patients. In PASI score, Calcipotriol s...
Faiza Hassan1, Mubshara Saadia1,*, Muhammad Sher1, Mian Anjum Murtaza2, Muhammad Arshad3,Asam Riaz4 and Mahmood Ahmad Khan5
...of diabetes by synthetic drugs has been found cost effective with severe side effects as well. Herbal remedies are gaining popularity. Black cumin and garlic are found effective against hypoglycemia, hyperlipidemia, and hypercholesterolemia. Present study was designed to evaluate the relative antidiabetic potential of garlic aqueous (AGE) and petroleum ether (EGE) extracts compared to black cumin (Nigella sativa oil; NSO) and insulin. Alloxan induced di...
Muhammad Yahya Noori1*, Saharish Rizwan2, Zaheer Ali3 and Shaheen Sharafat4
...ents suffering from Multidrug resistant (MDR) Tuberculosis by assessing their contact information. Data were obtained and analyzed from 164 individuals suffering from MDR TB. Records were scanned to evaluate the presence of a close contact with known history of Tuberculosis. Tabulations and analysis were performed in Microsoft Excel® and online calculators. Analysis of contact data showed that only 36% of the patients had a close contact with a known Tuber...
Mahboob Ali1, Muhammad Avais1, Riaz Hussain2, Kashif Prince1,*, Muhammad Ijaz1, Mamoona Chaudhry 3, Sehrish Firyal4, Amjad Islam Aqib1, Naimat Ullah Khan5 , Mian Saeed Sarwar5, Hazrat Ali5, Shahid Hussain Farooqi1, Ikramul Haq1 and Muhammad Sajid Hasni3
...>is emerging as multiple drug resistant (MDR) pathogens in milk of camels with characteristically zoonotic potential. Current study was planned to investigate epidemiology of MDR S. aureus in camel milk, and in-vitro therapeutic response to drugs. Two different ecological zones, Cholistan (n=185) and Suleiman Range (n=177) of Pakistan having major population of camel were screened for subclinical mastitis using...
Mian Sajjad Ahmad1, Somia Iqtadar1, Sami Ullah Mumtaz1*, Zafar Niaz1, Iqra Waheed2 and Sajid Abaidullah1
... physical exercise & drugs should be taken to control obesity. ...
Promy Virk
...n was used as a standard drug. The results of Zetasizer and Transmission and Scanning Electron Microscopy images showed the presence of spherical to irregularly shaped green gold and silver (Au/Ag) nanopcomposite with an average size of 73.18 nm with polydispersity. A typical optical absorption peak at approximately 2.30 keV and 3.0 keV corresponded to the surface plasmon resonance property of gold and silver nanoparticles respectively. The green gold and silv...
Anish Shrestha
...and expenditure on sugar drug and comb foundation seems to have positive and significant relation with gross return. All of them appeared to be underutilized and needed to be increased by 39%, 74% and 34% respectively for the profit maximization. Main production problem found to be high cost and inadequate availability of modern equipment with the index score of 0.81. And, according to the farmers, main role institution that should play is providing training t...
Muhammad Hidayat Rasool*, Abuzar Muhammad Afzal*, Abu Baker Siddique*, Waseem Akram**, Muhammad Saqalein*, Madiha Basit* and Muhammad Farooq Tahir***
ANTIVIRAL ACTIVITY OF VIRO CARE GZ-08 AGAINST NEWCASTLE DISEASE VIRUS IN POULTRY AND ITS IN-VITRO CYTOTOXICITY ASSAY
...evelop a novel antiviral drug against NDV in poultry....
Samina Ashraf1*, Ghulam Haider2 and Maimoona Ashraf3
... institutional violence, drug use, undesirable sterilisation, medical abuse, mortification, and nuisance. This study is intended to explore the lived experiences of women with disabilities who have been subjected to any type of violence, generate a theoretical model for the ways in which women with disabilities survived and coped with their violence and finally to make suggestions and recommendations in order to reduce the elements causing violence against wom...
Musrrat Fatima, Muhammad Saad Khan, Hamid Rashid, Asim Mehmood, Sumaira Kanwal, Muhammad Asif Rasheed and Farrukh Jamil*
...ere is a need to develop drugs against ZIKV. Here we uses pharmacoinformatics techniques to identify potential inhibitors against ZIKV protease NS2B-NS3, which has a well-known role in the viral replication. By using three dimensional structure of the NS2B-NS3, an allosteric site has been identified in the protein. Moreover, the identified site is used for structure-based virtual screening. After screening 100,000 compounds, 14 compounds are selected, which fu...
Muhammad Shahid Saeed1, Adeela Shahid2, Samia Jawed3, Muhammad Akram4, Irshad Hussain Qureshi5
... factors. There are many drugs available for asthma and magnesium sulphate is given intravenously as an important adjunct therapy during the acute severe attack of asthma
Objective: This study was panned to determine the effect of intravenous MgSO4 on pulmonary function test in acute severe attack of asthma.
Methodology: A double blind placebo control study was conduced on about 132 asthmatics, which were aged b...
Muhammad Kashif Munir1*, Sana Rehman1, Rizwan Iqbal1, Muhammad Saqib Saeed2, Muhammad Aasim1
...tagious disease and multidrug resistant tuberculosis is an emerging global issue. Rapid detection of such type of tuberculosis is necessary for timely control of the disease. GeneXpert test has already been implemented by World Health Organization to diagnose the infection on urgent basis.
Objectives: This study was designed to apply GeneXpert MTB/RIF assays for the detection of rifampicin resistant tuberculosis and validation of assays by c...
Sahar Naz1, Farhan Rasheed2, Muhammad Saeed3*, Shagufta Iram4 and Ambereen Anwar Imran5
...mains the only choice of drug for MβL positive and Negative isolates with 0% resistant rate except for Proteus species, to which it is intrinsically resistant.
...
Zartasha Anjum1*, Rakhshindah Bajwa2 and Munazza Hassan3
...ct | Statins are the drugs that target 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR). Several studies have reported the anti-tumoral properties of statins by exhibiting anti-proliferative properties in HMG-CoAR positive breast carcinomas. Increased efficacy has also been observed when these were used as combination therapy along with tamoxifen in estrogen receptor (ER) and HMG-COAR positive breast carcinomas. However, in our local population, ...
Ayesha Noreen1, Dilara A. Bukhari2 and Abdul Rehman1,*
...ke, tobacco, xenobiotic, drugs, medical materials, radiations, pesticides, industrial solvents and ozone. The processes running in the cell membranes, peroxisomes, mitochondria and endoplasmic reticulum also generate ROS. ROS can be activated by numerous external factors, and play an important role in cancer growth and metastasis. ROS and tumor cell interaction could activate the signalling pathways, promoting cell proliferation, invasion, inducing angiogenesi...
Madeeha Arshad1, Asmatullah1, Chaman Ara1, Shagufta Andleeb2 and Naveed Ahmad3,*
...nt concentrations of the drug, 0.00, 4.10, 8.33 and 16.66 µg/g B.W. were administered orally to the dams on days 6-12 of gestation, and fetuses were recovered on day 18. Morphological observations of fetuses from 4.10, 8.33 and 16.66 µg/g B.W. dose groups showed abnormalities such as skin hemorrhages, microphthalmia, limb deformities, hygromas, kyphosis, curved and short tail and fluid filled abdominal cysts. Significant increase in intrauterine gr...
Syed Aun Muhammad1, Muhammad Soaib Said2, Shams Ur Rehman2, Muhammad Dawood2, Muneer Ahmed Qazi3 and Nighat Fatima2,*
...d for discovery of novel drugs with selective potential. In this study, we illuminate the binding mode of pimarane diterpenes (diaporthein A and diaporthein B) to the NMD-1 by molecular docking. A computational ligand-target docking approach was used to analyze structural complexes of enzyme target with diaportheins. Auto Grid model showed the most energetically favorable binding mode of natural compounds to beta-lactamase. Docked energies for diaporthein A an...
Mohammed Zaki Fathy*
...mg/Kg) as pre-medication drug intravenously. Then in the first group (G1), was injected by the propofol (2mg/Kg intravenously) while in the second group (G2), was injected with ketamine HCl (2.2mg/Kg intravenously). The onset, duration, and recovery times were recorded for each group. Heart rate, respiratory rates, and rectal temperature were recorded. Blood samples were collected at 0, 20, 40, 80 minutes and 12 hours after administration for detection the hem...
Safia Rehman1, Nazish Mazhar Ali1,*, Gerald B. Pier2, Iram Liaqat1 and Bushra Mazhar1
...tic methods against multidrug resistant bacterial pathogens in chronic and acute lung infections. It provides a practical approach towards the use of nanoparticles to enhance antimicrobial activity against these pathogens.
...
Hafiz Manzoor Ahmad1,*, Hamad Bin Rashid1, Muhammad Arif Khan1, Asim Khalid Mahmood1, Muhammad Ijaz1, Shahid Hussain Farooqi1, Muhammad Rafi Ullah2 and Usman Ghani1
...use of single anesthetic drug has failed to induce a safe and deep anesthesia for surgical as well as painful conditions. However, this problem can be solved with usage of anesthetic combinations. This study was aimed at comparative evaluation of two anesthetics combinations viz. ketamine-xyalzine (K+X) and ketamine-xylazine-diazepam (K+X+D). A total of 20 ducks presented at pet center University of Veterinary and Animal Sciences Lahore were divided int...
Asinamai Athliamai Bitrus1*, Olabode Mayowa Peter2, Muhammad Adamu Abbas3 and Mohammed Dauda Goni4
...flux pump, alteration of drug target site, enzymatic inactivation and, mutation in drug target site and gene acquisition of resistance determinants through horizontal gene transfer. This review focused on the mechanisms of antimicrobial resistance in S. aureus. Understanding the concept of resistance development and transfer will immensely help in curtailing the global rise in antimicrobial resistance in bacteria. ...
Rida Zainab1, Sana Elahi1, Afshan Kaleem2,*, Daniel C. Hoessli3, Mehwish Iqtedar2, Roheena Abdullah2, Faiza Saleem2, Shanza Khan1, Anusha Ijaz1, Shagufta Naz2 and Abdul R. Shakoori4,5,*
... A novel, computer-based drug designing technique, has emerged to develop more efficient drugs. One of the computational methods becoming increasingly popular to develop new drugs is relying on Pharmacophores. This method was utilized to develop pharmacophore models of Akt2 inhibitors and β2-Adrenoceptor agonists. A pharmacophore model is proposed, using fourteen second generation and...
Junaid Akhtar1,2, Sidrah Saleem1, Naveed Shahzad3, Abdul Waheed1, Iqra Jameel1, Farhan Rasheed4 and Shah Jahan5,*
...ent option against multi-drug resistance GNR infections. However, the emergence of carbapenemases particularly metallo β-lactamases (MBLs) in bacteria have severely mitigated the efficiency of carbapenems. MBLs producing gram-negative bacteria have been reported from various hospital settings, worldwide. However, data is lacking in Pakistan regarding their frequency particularly among GNRs. Therefore, the present study aimed at determining the frequency o...
Nimra Naseer, Adeela Fatima and Imran Sajid*
...emerging problem of multidrug resistant (MDR) pathogens, there is a demand of novel biological active compounds to replace currently used antibiotics in order to evade resistance. Currently, the pathogenic organisms of concern are methicillin and vancomycin resistant strains of Staphylococcus aureus, Acinetobacter spp., extended spectrum β-lactamases (ESBLs) producing strains of Escherichia coli, Klebsiella spp., Pseudomonas...
Muhammad Khan
...ing new uses of existing drugs) has offered a novel strategy for discovering new anticancer drugs from non-cancer drugs. Drug repurposing has attracted the attention of scientific community involved in anticancer drug discovery because it is cost effective and less time consuming compared to the conventional
Amjad Islam Aqib1,*, Shagufta Nighat2, Rais Ahmed3, Saba Sana3, Muhammad Ameen Jamal4, Muhammad Fakhar-e-Alam Kulyar2 , Naimat Ullah Khan5, Mian Saeed Sarwar5, Muhammad Asif Hussain5, Asadullah5, Attaur Rahman5 and Sadeeq ur Rahman5,*
...ns, macrolides and other drugs showed that 50% of CPS and 30% of CNS were found multi-drug resistant-exhibiting resistance against more than two or more than two classes of drugs. None of the CPS while 20 % from CNS isolates were 100% susceptible to all kinds of drugs tested. Finally, age, grazing system, use of beta-lactam antibiotics, parity, and poor ...
Tasleem Akhtar, Nadeem Sheikh*
Induction of acute phase in response to tacrolimus induced hepatotoxicity
... of an immunosuppressive drug (tacrolimus). Aqueous suspension of tacrolimus powder (3 mg/ml) was orally given to four experimental groups of wistar rats. Control group was provided with normal drinking water and dissections were done after 6, 12, 24 and 48 h of tacrolimus dose. Densitometric analysis revealed considerable elevated level of some positive acute phase proteins, specifically C-reactive protein, haptoglobin and ceruloplasmin. While albumin and tra...
Saiqa Andleeb* , Shaukat Ali
RNA interference; A tool for treatment of human diseases
... of RNAi technology as a drug therapy against various human disorders....
Shaukat Ali1,*, Sundas Nasreen1, Sobia Safeer1, Saiqa Andleeb1, Mubashir Ejaz1, Saira Bano2, Hafiz Abdullah Shakir3
Medicinal plants as therapeutic agents for cancer treatment
...otent natural sources of drugs to treat different human inflammations since ancient time. Many
of anticancer lead bioactive molecules such as vinca alkaloid, vinblastine, vincristine, camptothecin, and taxanes
have been characterized from different medicinal plants and are used as therapeutic agents in worldwide. Technical
strategies based on the natural yield of drug innovation, ethnomedicines and tradi...
of anticancer lead bioactive molecules such as vinca alkaloid, vinblastine, vincristine, camptothecin, and taxanes
have been characterized from different medicinal plants and are used as therapeutic agents in worldwide. Technical
strategies based on the natural yield of drug innovation, ethnomedicines and tradi...
Muhammad Saqib Shahzad1, Amina Arif1,*,Saeeda Kalsoom2, Javed Iqbal3, Shahnam Shafique2, Muhammad Shahid Nadeem4 and Rafique Ahmed5
...ed pre and post combined drug therapy during the period 2015-2017. Distribution of HCV genotypes, age groups, viral load and alanine aminotransferase (ALT) values were recorded and analyzed for rapid virologic response (RVR), non-rapid virologic response (NRVR), sustained virologic response (SVR) and non-sustained virologic response (NSVR). Among the evaluated patients RVR was found among 81.5% and NRVR among 18.5%. Out of RVR patients, SVR was found in majori...
Zhen-li Li1,2, Hui-fang Zhou2,*, Bo-ru Zhou2, Bei Liu2, Xiao-fei Jiang2 and Jian-ya Xu2
...x hormones persist after drug discontinuation, possibly leading to luteal phase defect (LPD) and infertility. Recent studies revealed that mifepristone not only affects the ovary and uterus, but also the pituitary, resulting in LPD. Bu Shen Zhu Yun formula (BSZYF) was developed by Professor Guicheng Xia, a “great master in TCM.” It effectively cures LPD, while its effect on the pituitary is unclear. In this study, we aimed to explore the effect of ...
Abdul Wahaab1, Muhammad Ijaz1,*, Syed Saleem Ahmad1, Umair Iqbal2, Abdul Tawaab1 and Iahtasham Khan3
...oups of 10 animals each, drug was administered to first three groups whereas last one was kept under positive control for comparison. Study revealed that Triclabendazole was most effective drug of all three in both cattle and buffaloes with efficacy of 97.92% and 100%, respectively; Oxyclozanide was 2nd most effective with efficacy of 96.87% and 97.05% % whereas Nitroxynil remained at last with efficacy of 93.47% ...
Muhammad Hidayat Rasool1,*, Muhammad Zaheer1, Muhammad Farooque Hassan2, Muhammad Shafique1 and Muhammad Usman Qamar1
...s were resistant towards drugs such as cephalosporin, ceftazidime but majority of them were sensitive to polymyxins, tazocin and fusidic acid. Proper screening of MBLs producing GNRs should be done from clinical specimens along with antimicrobial susceptibility testing for developing an effective treatment strategy and thus better control of infections caused by these bugs in future.
...
Sabi-Ur-Rehman1, Anwar Khalid2, Qazi Najam Us Saqib3, Farooq Ahmad1, Shaheed-Ur-Rehman4, Neelam Zaman3, Ayeza Mehmood5 and Abdul Samad6*
...r to overcome antibiotic drugs resistance, plants provide source for discovery of new antimicrobial drugs. This study was carried out, include in-vitro antibacterial and antifungal screening of aqueous methanolic extracts as well as crude saponins isolated from leaves and roots of Sarcococca saligna, using disc diffusion method. The tested bacterial strains include, B. subtilis, E. coli, S. aureus, P. fluorescens and fungal ...
Abdul Maalik1, Shahzad Ali1,*, Anam Iftikhar1, Muhammad Rizwan1, Haroon Ahmad2 and Iahtasham Khan1
...was concluded that multi-drug resistant strains of Staph. aureus were major causative agent of bovine subclinical mastitis and there were multiple risk factors associated with incidence of mastitis....
Sumreen Hayat1,6, Muhammad Hussnain Siddique2, Bilal Aslam1, Habibullah Nadeem2, Asma Ashraf3, Muhammad Saqalein1, Mohsin Khurshid4, Naveed Shahzad5 and Saima Muzammil1,*
.... The studyrevealed multidrug resistance phenotypes among K. pneumoniae isolates with higher prevalence of ESBL producing Klebsiella pneumoniae among the children with urinary tract infections. Based on our findings, it is recommended that the ESBL production should be routinely monitored especially among the K. pneumoniae strains for the effective management and control of such MDR pathogens.
...
Mehboob Arslan* and Xin Yang
...mprove the diagnosis and drug development of future antiviral therapeutics. In fact, metabolism is considered as a crucial player in the cascade of viral interactions, its modulation is essential to decide the final outcome of viral infection. Here, we concisely present how viruses alter the metabolic pathways for their own survival. ...
Sher Bahadar Khan1,2,*, Zou Geng1, Cheng Yu-ting1, Asad Sultan3, Mumtaz Ali4,5, Irshad Ahmad6 and Rui Zhou1
...valent. Besides multiple drug resistance, they share many traits with the human pathogenic isolates based on virulence gene contents that may pose a potential threat to public health....
Wali Khan1,*, Mudassar Iqbal2 and Israr Khan2
...s. Therefore both of the drugs used are equally contributed in the controlling of intestinal parasitic diseases in children.
...
Abid Hussain Shahzad1, Abdul Sattar1,*, Nasim Ahmad1, Ijaz Ahmad2, Deniz Nak3 and Yavuz Nak3
...n of controlled internal drug release (CIDR) inserts for 5 or 7 days, respectively. Pregnancy was diagnosed using ultrasonography on d30, d60 and d90 post AI. Ovulatory follicle diameter was measured at timed AI and progesterone profile (ng/mL) on d30 and d60 post AI. Pregnancy rate was analyzed by Chi-square procedure while ovulatory follicle diameter and Progesterone profile by one way ANOVA (α=0.05). Ovulatory follicle diameter (Mean±SEM) was 1...
Uzma Jabeen1, Irfan Khan2, Nadia Naeem2, Asmat Salim2,* and Waseem Ahmed1
...ly used chemotherapeutic drug. Oxidative stress plays an important role in DOX-induced toxicity. This study was aimed at analyzing the expression levels of genes that are induced in response to oxidative stress in heart and liver tissues following DOX administration to rats. In this study, DOX was administered to rats intraperitoneally (i. p.) at 3 mg/kg at alternate days for two weeks. Heart and liver tissues were harvested and the mRNA levels of NAD(P)H quin...
Shafqat Husnain Khan1, Shah Jahan2, Irshad Ahmad3,4, Sadeeq ur Rahman5,* and Tayyab ur Rehman4,*
...es.
... 
