Isoconversional Thermal Analysis of Cydonia oblonga Mucilage Composite Wound Dressing
Isoconversional Thermal Analysis of Cydonia oblonga Mucilage Composite Wound Dressing
Aniqa Nasir1, Rashid Masih1, Shazma Massey1*, Laiba Arshad2, Sabi Ur Rehman2, Irva Waqar1 and Anwar Khalid3
ABSTRACT
Stability and shelf life of commodities are crucial aspect in product development in the field of pharmaceutics, food, and other consumer goods. In today’s world, non-adherent bandages are essential for reducing the pain and discomfort of people after surgery. In the present study, Cydonia oblonga mucilage was used to prepare non-adherent wound dressing and its stability is determined by thermal analysis by using advanced isoconversional method. Isoconversional method is used to determine kinetic triplet including activation energy, pre-exponential factor and mechanism of thermal degradation. The prepared dressings were subjected to thermal analysis. Thermogravimetric analysis showed that the degradation of wound dressing occurs at 225˚C - 400˚C. Thus, the dressing was found to be stable up to wide ranges of temperature. Kinetics of thermal degradation was also studied by model-free isoconversional analysis. Activation energy, pre-exponential factor and decomposition mechanism model was determined by Starink method. The average activation energy of Cydonia oblonga wound dressing with and without drug was 111 kJ mol-1and 103 kJ mol-1 respectively and the pre-exponential factor values are 236751615 s-1 and 49975394 s-1 respectively. The wound dressing shows a distinct behavior of decomposition. Decomposition of wound dressing with drug followed two-dimensional diffusion mechanism model and wound dressing without drug followed three-dimensional diffusion mechanism. The value of kinetic parameters of wound dressing shows that both dressings with and without drug are stable but if these are compared with one another then with drug wound dressing is more stable as its activation energy is high.
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