Pomegranate Juice Ameliorates Fetotoxic Effects of Atenolol in Developing Mice (Mus musculus)
Pomegranate Juice Ameliorates Fetotoxic Effects of Atenolol in Developing Mice (Mus musculus)
Sara Zafar* and Asmatullah
ABSTRACT
Our objective was to assess the fetotoxic effect of a commonly used antihypertensive drug, atenolol during gestation and ameliorative effect of pomegranate juice against its toxicity. Dose was administered to pregnant mice by gavage. The high dose contains Atenolol 2.5 µg/g body weight (B.wt.) of treated mice and low dose contains 1.65 µg/g B.wt. The dose was administered from the 6th -12th day of the gestation period for seven days. Many congenital abnormalities including hemorrhages, hygromas, resorbed fetuses, deformed, hyperextended and hyperactive flexed limbs, distorted axis, and intrauterine growth retardation was found. The present study revealed that the administration of Atenolol, especially during the organo-genetic period, can cause harm to the developing embryo and Pomegranate juice significantly reduced the detrimental effects caused by atenolol.
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October 2020
Vol. 52, Iss. 5, Pages 1631-2026
