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Identification of the Top 10 Core Genes as Diagnostic and Therapeutic Targets in Hepatocellular Carcinoma (HCC)

Identification of the Top 10 Core Genes as Diagnostic and Therapeutic Targets in Hepatocellular Carcinoma (HCC)

Qiangsheng Wu1, Yumei Yin2, Hui Gao1, Baoding Chen3, Jianjun Yu2, Jian Zhang4, Donglai Zhu5, Fang Liu6, Guohong Ge7 and Ya-Mei Dang8*

1Department of Assay Development, Eoto-Biotech Co., Ltd, Shenzhen, Guangdong 518000, China.
2Department of Medical Ultrasound, The Third People’s Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang, Jiangsu 212005, China.
3Department of Medical Ultrasound, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China.
4Department of Radiology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China.
5Department of Clinical Laboratory, The Third People’s Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang, Jiangsu 212005, China.
6Department of Computer, Anhui Medical University, Hefei, Anhui 230032, China.
7Department of Hepatosis, The Third People’s Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang, Jiangsu 212005, China. 
8Department of Pathology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, China.
 
Qiangsheng Wu, Yumei Yin and Hui Gao contributed equally to this work.
 
*      Corresponding author: yameidanggs@126.com

ABSTRACT

Lacking specific diagnostic markers for hepatocellular carcinoma is the critical reason for its increasing mortality. In this study, a microarray containing 24 hepatocellular carcinoma patients’ tumor tissues were compared to 8 normal liver tissues to screen out the significant abnormal expressed genes. The potential interactions and mechanisms of these genes in promoting hepatocellular carcinoma were analyzed through bioinformatics analysis. The results showed that the functions of these 1495 differently expressed genes enriched in cell cycle, oxidation-reduction and drug metabolic process. Additionally, the top 10 core genes of these differently expressed genes were mainly participated in cell cycle and strongly correlated with worse prognosis of survival, which may be potential diagnostic and therapeutic targets of HCC.

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Pakistan Journal of Zoology

June

Pakistan J. Zool., Vol. 56, Iss. 3, pp. 1001-1500

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