Compatibility of Intravenous Fat Emulsion and Antibiotics in Secondary Piggyback Transfusion
Compatibility of Intravenous Fat Emulsion and Antibiotics in Secondary Piggyback Transfusion
Nina Chen1, Shuang Xu2, Juanjuan Lin1* and Moslem Lari Najafi3
ABSTRACT
According to the change of fat particle size distribution, this study aimed explore the compatibility of fat emulsion and antibiotics in piggyback infusion. In this study 5% glucose solution, fat emulsion and mixture containing 25 kinds of antibiotics were prepared by the proportion suitable for piggyback infusion (33:10:40). The number of fine particles was analyzed by automatic particle counter. According to results, even 24 h after preparation, 12 β-lactam antibiotics, clindamycin phosphate, teicoplanin, trimethoprim/ sulfamethoxazole and micafungin sodium did not change significantly. The particle size of the mixture containing vancomycin hydrochloride, levofloxacin hydrate, metronidazole and fluconazole increased gradually. The particle size of fosfomycin sodium in the mixture containing gentamicin sulfate, abacain sulfate, minocycline hydrochloride, ciprofloxacin and/ or ciprofloxacin also changed significantly after preparation. We concluded the particle size changes of some drugs indicate that these drugs may cause changes in fat particle size during administration. Therefore, these antibiotic preparations should not be administered in conjunction with fat emulsion.
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