In vitro Antihelminthic Activities of Artocarpus heterophyllus (Jackfruit) and Artocarpus camansi (Breadnut) Leaf Extracts on the Model Nematode, Caenorhabditis elegans
In vitro Antihelminthic Activities of Artocarpus heterophyllus (Jackfruit) and Artocarpus camansi (Breadnut) Leaf Extracts on the Model Nematode, Caenorhabditis elegans
Estrelle Anne Tacbas1, Neil Pep Dave Sumaya2 and Nanette Hope Sumaya1,3*
ABSTRACT
Caenorhabditis elegans can represent a model organism for herbal medication against parasitic nematodes in determining the anthelmintic potential for the following concentrations of Artocarpus heterophyllus and Artocarpus camansi, 10000 ppm, 7500 ppm, 5000 ppm. The phytochemical results revealed the presence of alkaloids, flavonoids, saponins, steroids, and tannins in both plant crude extracts. Different developmental stages of C. elegans (i.e., 1st to 4th larval stages (L1-L4), young adult (YA) and adult nematodes) were used for in vitro anthelmintic assay, mortality, development of life stages, and reproduction of the nematode. Both plant extracts caused high mortality in the L4 stage for their LC50 and LC90 values. Notably, the crude extracts of both plants delayed the development of L4 for almost 48 hours. Thus, the results suggest that the extracts of A. heterophyllus and A. camansi can be a potential alternative for anthelmintic treatment or with further research, can be utilized as a natural source and active ingredient for a bio-based antihelmintic pharmaceutical drug.
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