Evaluation of Oxidative Stress and Some Biochemical Criteria in Male Rabbits Following Administration of Aspartame
Evaluation of Oxidative Stress and Some Biochemical Criteria in Male Rabbits Following Administration of Aspartame
Shireen Ali Hasan1*, Ahlam A. Al-Rikaby2, Maitham Ali Al-Rikaby3
ABSTRACT
Since aspartame (L-aspartyl-L-phenylalanine-I-methyl ester, ASP) is one of the most widely used nonnutritive synthetic sweetener added to a wide variety of food products and drugs that are consumed by about 70% of the population. The present work carried out to assess whether the daily administration of ASP induced alteration in body weight and biochemical indices in male rabbits. Eighteen rabbits were used and distributed randomly into three groups, group one considered as control which was administered 1ml of distilled water orally, group two was administered 40mg/kg of aspartame orally, group three was administered 80 mg/kg of aspartame orally, the administration of aspartame continue for 45 days. Our findings revealed that the administration of ASP significantly affected all the studied parameters in both doses (low and high). After 45 days, there was body weight gain and significantly increased level of malondialdehyde (MDA) which was accompanied by a significant elevation in blood glucose, TC, TG and LDL-c. However, a significant reduction in the level of HDL-c was noticed. Additionally, a significantly increased activity of liver enzymes of ALT, AST and ALP were observed after 45 days of treatment at both doses of aspartame. Taken together, it can be concluded that the long consumption of aspartame leads to weight gain, hyperglycemia, hyperlipideamia and liver dysfunction, and highlight the use of animal models to assess important aspect of health.
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