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Effect of Chelidonium majus L. Root Extract on Cyclophosphamide-Induced Testicular Toxicity in Rats

Effect of Chelidonium majus L. Root Extract on Cyclophosphamide-Induced Testicular Toxicity in Rats

Amer Hakeem Chyad1, Omar S.I. Al-Janabi2*, Orooba Mohammed Saeed Ibrahim1, Najeeb Mohaamed Hussein3

1Department of Physiology and Pharmacology, College of Veterinary Medicine, Baghdad University, Iraq; 2Department of pharmacology, College of Medicine, University of Al-Anbar, Iraq; 3Department of Food Sciences, Collage of Agriculture, University of Anbar, Iraq.
 
*Correspondence | Omar S.I. Al-Janabi, Department of pharmacology, College of Medicine, University of Al-Anbar, Iraq; Email: dr.osin1981@uoanbar.edu.iq

ABSTRACT

Cyclophosphamide (CP) is a chemical drug that can induce infertility and have adverse effects on various organs, including male reproductive system. In the present investigation, we investigated the effect of oral administration of Chelidonium majus L. root extract on the testes of rats. Fifty adult male rate were divided into five equal groups, and each group received thirty days of treatment. first group (G1). Gave only distilled water (negative control group). second group (G2). These animals were administered CP at a dose of 14.2 mg/kg/BW (positive control group). third party (G3). Gave only 200 mg/kg/B.W. of Chelidonium majus alcoholic extract and 14.2 mg/kg/B.W. of cyclophosphamide were administered orally via gastric tube. Fourth group (G4): These animals were administered 300 mg/kg/B.W. of Chelidonium majus L. alcoholic extract and 14.2 mg/kg/B.W. of cyclophosphamide orally via gastric tube. Five groups (G5) Animals of this group were administered 400 mg/kg/B.W. of Chelidonium majus L. alcoholic extract and 14.2 mg/kg/B.W. of cyclophosphamide orally via gastric tube. Chelidonium majus L. roots extract significantly altered all tested parameters (sperm count, total testosterone levels, FSH, and LH) compared to the CP group (P 0.05). Root extract of Chelidonium majus L. can be administered. Increase in all parameters and decrease in CP’s adverse effects on the testis.
 
Keywords | Herbal medicine, Biochemical indices, Chelidonium majus L. roots extract, Sperm count, Testosterone, FSH, LH and Cyclophosphamide

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Advances in Animal and Veterinary Sciences

June

Vol. 12, Iss. 6, pp. 994-1205

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