A Review of 20 Years Research Progression on Prodrug Technology in Inhaled Medications
A Review of 20 Years Research Progression on Prodrug Technology in Inhaled Medications
Lijuan Liu1, Jinghang Chen2*, Min Wang3 and Wei Li4
ABSTRACT
In contrast to systemic administration methods such as oral or injection, inhaled medications are directly administered to the respiratory tract to exert a therapeutic impact, which has clear benefits in the treatment of respiratory illnesses. However, existing inhaled medications are difficult to fulfill clinical prescription demands, and the research and development of novel inhaled pharmaceuticals has significant hurdles due to a lack of comprehensive theoretical and practical experience guidance. Personalized customization of candidate pharmaceuticals to fulfill the needs of inhalation treatment using prodrug technology is now an alternate method of inhalation drug development. This article examines the use of prodrug technology in inhalation administration throughout the last 20 years. These studies discovered that: esterification modification or prodrug technology combined with macromolecular compounds can extend drug pulmonary residence; mannose modification or acid-sensitive bond linkage can achieve drug release in alveolar macrophages; and personalized modified prodrugs can achieve drug release in alveolar macrophages. It is possible to produce physicochemical qualities suited for inhalation administration while reducing medication toxicity. Overall, using prodrug technology may be able to meet the different needs of inhaled drug development and give ideas for how to make new inhaled drugs.
To share on other social networks, click on any share button. What are these?
