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Study the Effects of Sub-chronic Exposure to Meloxicam on Some Hematological and Liver Function Parameters in Rats and the Role of Beetroots Ethanolic Extract

Study the Effects of Sub-chronic Exposure to Meloxicam on Some Hematological and Liver Function Parameters in Rats and the Role of Beetroots Ethanolic Extract

Salma Jameel Askar 

Department Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine , University of Baghdad, Iraq.

*Correspondence | Salma Jameel Askar, Department Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine , University of Baghdad, Iraq; Email: d.salma@covm.uobaghdad.edu.iq  

ABSTRACT

One of the greatest treatment options for preventing and treating postoperative pain is nonsteroidal anti-inflammatory drugs, suppression of cyclooxygenase (COX-1) activity by these drugs has been associated with substantial side effects, beetroots act as a medicinal herb in the treatment of hematological disorders, and act as antioxidant. The aim of this study was to examine the effects of sub-chronic exposure to meloxicam, nonsteroidal anti-inflammatory drug, on hematological alterations and liver functions parameters in albino male rats and to determine the effects of Beetroots ethanolic extract in alleviation these alterations. Eighteen male albino rats were used, and they were divided into three groups of six animals each: G1, which received a dose of distilled water as a negative control; G2, which received a dose of meloxicam at 1.3 mg/kg.BW was a positive control, and G3 received a dose of meloxicam and beetroots ethanolic extract. Each animal received a single oral dosage of (0.1ml/100gm ) B.W. for six weeks. Red blood cells count, platelets counts, packed cell volume (PCV) percentages, and hemoglobin (Hb) concentrations, clotting times, levels of uric acid and liver enzymes were analyzed. RBCs, platelets, PCV%, and Hb concentration all decreased significantly at in the G2 compared to G1 while clotting time, serum uric acid, blood urea nitrogen levels, and liver enzyme functions all increased significantly. Rats in G3 had significantly higher RBCs, platelets, PCV%, and Hb concentrations, while clotting time, serum uric acid, and blood urea nitrogen levels, and liver enzyme functions were all significantly reduced in comparison to G2. Liver section of G2 showed increased Kupffer cell proliferation, enlarged and apoptotic hepatocytes. Liver sections of G3 showed less side effect than Meloxicam-treated group. From this study concluded supplementation with beetroots ethanolic extract may attenuate the toxicity of Meloxicam, leading us to deduce that Meloxicam induces hepatotoxicity and creates abnormalities in hematological and biochemical markers. 

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Advances in Animal and Veterinary Sciences

June

Vol. 12, Iss. 6, pp. 994-1205

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