Comparative Efficacy of Triclabendazole, Oxyclozanide and Nitroxynil against Bovine Fasciolosis in Gomal Zam Dam Command Areas of District Tank, Khyber Pakhtunkhwa
Comparative Efficacy of Triclabendazole, Oxyclozanide and Nitroxynil against Bovine Fasciolosis in Gomal Zam Dam Command Areas of District Tank, Khyber Pakhtunkhwa
Imtiaz Khan1, Arsalan Khan2*, Umme Aimen2, Waseem Ullah2, Akhtar Ali2, Qamar Ullah3, Muhammad Faimullah Khan4, Abdul Wadood Jan5, Salma Zaman6, Abdul Qadoos1, Tayyeb Ullah7
ABSTRACT
The objective of this investigation was to assess the efficacy of three distinct anthelmintics; oxyclozanide, nitroxynil and triclabendazole, in the treatment of Fasciola hepatica species in cattle that have contracted the disease naturally at a dairy farm in district Tank, Khyber Pakhtunkhwa. The trial involved the selection of 40 dairy cattle, which were divided into three treated groups and one untreated control group. A single anthelmintic drug was administered to each cohort on day zero. Fecal samples were collected from each animal in the groups on the first, seventh, fourteenth, twenty-eighth, sixty-fifth and eightieth days following treatment. The efficacy of the anthelmintics was determined by the percent reduction in fecal egg count, which was conducted using the McMaster technique. The fecal egg count was reduced by 100% on the 28th day post-treatment and oxyclozanide and nitroxynil treated groups exhibited high efficacy against Fasciola hepatica. Simultaneously, triclabendazole group demonstrated lower efficacy levels in this trial, with a maximal reduction in fecal egg count (93.74%) and a mean value of 90.23% post-treatment. Nitroxynil and oxyclozanide were more effective against the Fasciola hepatica species than triclabendazole, as indicated by these results. The results of the triclabendazole study indicated that the Fasciola hepatica species in dairy cattle in the Tank Area are developing resistance to the drug.
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