Estimate the Effect of Propofol and Ketamine on Clinical and Hematological Parameters in Xylazine Pre-Meditated Baladi Egyptian Donkeys
Estimate the Effect of Propofol and Ketamine on Clinical and Hematological Parameters in Xylazine Pre-Meditated Baladi Egyptian Donkeys
Mohammed Zaki Fathy*
ABSTRACT
This study aimed to compare the effect of propofol and ketamine on hematological parameters and cardiopulmonary parameters in xylazine pre-medicated Baladi Egyptian donkeys. Eighteen apparently healthy donkeys were divided into two equal groups. All animals were injected with xylazine HCl 2% (1.0mg/Kg) as pre-medication drug intravenously. Then in the first group (G1), was injected by the propofol (2mg/Kg intravenously) while in the second group (G2), was injected with ketamine HCl (2.2mg/Kg intravenously). The onset, duration, and recovery times were recorded for each group. Heart rate, respiratory rates, and rectal temperature were recorded. Blood samples were collected at 0, 20, 40, 80 minutes and 12 hours after administration for detection the hematological changes. Results showed that the onset, duration and total recovery times of anesthesia were 7.33±3.05 min and 3.33±1.53 min, 26.33±3.51 min and 45±3.00 min and 64±4.58 min and 86.67±6.11 min in G1 and G2 respectively. In G1, presence of a significant decrease in RBCs, PCV and Hb values and apnea was recorded. However, non-significant hematological changes were reported in G2. In conclusion, ketamine was produced by rapid induction, long duration, smooth recovery and satisfactory anesthesia without any significant cardio-respiratory changes and produced good and produce efficiently anesthesia in xylazine pre-medicated Baladi Egyptian donkeys in compare with the propofol.
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