Proscillaradin A: From Cardiac Glycosides to Cancer Therapeutics
Proscillaradin A: From Cardiac Glycosides to Cancer Therapeutics
Muhammad Khan
ABSTRACT
Drug repurposing (finding new uses of existing drugs) has offered a novel strategy for discovering new anticancer drugs from non-cancer drugs. Drug repurposing has attracted the attention of scientific community involved in anticancer drug discovery because it is cost effective and less time consuming compared to the conventional drug discovery strategy involving de novo identification, characterization and validation of new bioactive molecules. Proscillaridin A (PSD-A), is a natural cardiac glycoside molecule used to treat cardiac arrhythmia. Recently, it has been rediscovered for its potential anticancer activity. This review will mainly focus on the anticancer activity, cellular targets and anticancer mechanism of PSD-A which may help the further design and conduct of research and repositioning it for oncological clinic.
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December 2018
Vol. 33, Iss. 2, pp. 99-248
