Antioxidative and Haematopoietic Potential of Pelusios sinuatus (Turtle) Blood on Myelosuppressed Wistar Albino Rats
Antioxidative and Haematopoietic Potential of Pelusios sinuatus (Turtle) Blood on Myelosuppressed Wistar Albino Rats
Florence N. Nworah*, Nene O. Uchendu, Ifeoma F. Chukwuma*, Emmanuel C. Ossai and Emmanuel C. Ezeako
ABSTRACT
This study investigated the antioxidative and haematopoietic potency of the blood of Pelusios sinuatus (turtle) on cyclophosphamide induced myelosuppression in rats. Blood constituents were determined to identify the presence of vitamins and minerals. Thirty albino rats used were grouped into six comprising of five rats each and each group except group A was induced with cyclophosphamide. Group A received normal saline, group B remained untreated, group C, D, E and F were respectively treated with standard haematopoietic drug, Ginovera (5 mg/kg body weight), 50 and 100 mg/kg body weight of raw blood and 100 mg/kg body weight of cooked blood respectively. Determination of the constituents of turtle blood revealed the presence of vitamins such as Vitamin A, B6, B9 and B12 and minerals such as Selenium, Iron and Zinc. After the induction of myelosuppression, there was a significant (p<0.05) decrease in haematological parameters and a significant (p<0.05) increase in the concentrations and activities of oxidative stress biomarkers. However, treatment with the blood of P. sinuatus reversed the effect of cyclophosphamide on the haematological parameters and the oxidative stress biomarkers. These results suggest that the P. sinuatus blood exhibits both haematopoietic and antioxidative potential and could be a good source for the amelioration of leucopenia and anaemia.
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