Impact of Serratiopeptidase vs. N-Acetyl Cysteine (NAC) on Skin Grafting Healing in Albino Male Rabbits
Impact of Serratiopeptidase vs. N-Acetyl Cysteine (NAC) on Skin Grafting Healing in Albino Male Rabbits
Hasan Ali Al-Sailawi1, Araa Ali Hadi1, Hussein A. Raheem2, Mustafa Mudhafar3,4, Sahi J Dhahi5, Qais R. Lahhob6*
ABSTRACT
Skin grafting is a common dermatological wound closure procedure used to heal wounds caused by removing skin damage. Although grafting is less popular than flap closures, the aesthetic outcome can still be good. The present study aimed to investigate the grafting of the skin of albino male rabbits by N-acetyl cysteine (NAC) and Serratiopeptidase and then compare their effect on the skin grafting of rabbits. Nine rabbits were divided into three groups. Each group had three animals: Group 1 (G1) was used as a control (skin grafting without any drug), and the skin was taken from the shoulder to the femoral area. In group 2 (G2), the skin graft was taken from the same area in the G1 using Serratiopeptidase, while in group 3 (G3), the skin graft was taken from the same area in G1 using NAC. The outcomes demonstrated that Serratiopeptidase and NAC both had good enhancement effects on the skin graft and demonstrated superior effects on the AST, histology, and hematology parameters. According to our findings, the skin graft can be improved by using both NAC and serratopeptidase, which will raise the AST, histology, and hematology levels.
Keywords | Skin grafting, NAC, Serrati peptidase, hematology, histology, AST
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