Nayle Maria Oliveira da Silva1*, Ricardo do Carmo Zanella2
...stent hepatic parenchyma inflammatory process that may progress to cirrhosis and hepatocarcinoma. Viral clearance occurs in a minority of patients with viral hepatitis C, whereas chronic infection is established in 60 to 80% of all cases, 20 to 40% of which may evolve to cirrhosis and hepatocarcinoma. Genetic differences among infected hosts can determine the progression and outcome of the virus infection, causing different individuals to respond in different ...
Hu Zenglei1 and Xiufan Liu1, 2*
...ent innate antiviral and inflammatory response, and causes more severe damages in lymphoid tissues when compared with virulent viruses of other genotypes. Therefore, severe pathology in immune organs, caused by genotype VIId of NDV, is associated with high levels of virus replication and an intense innate immune response....
Muhammad Arif Zafar1*, Arfan Yousaf1, Murtaz-ul-Hasan1, Faisal Ayub Kiayani1, Matee ul Islam2 and Muhammad Farooq Iqbal1
...s and non-steroidal anti-inflammatory drug, good outcome in the calf was obtained. There was no postoperative complication suggesting that modified two-layer hand-sewn anastomosis technique was a successful technique. It was concluded that traumatic hernia may lead to septic shock and modified two-layer hand-sewn anastomosis technique may be recommended in calves with no postoperative complications and there is a good chance for long-term survival....
Iqra Mahmood1, Asif Nadeem1*, Masroor Ellahi Babar2, Muhammad Muddassir Ali1, Maryam Javed1, Aisha Siddiqa1, Tanveer Hussain2 and Muhammad Tariq Pervez2
...he understanding of this inflammatory disease and to identify potential genetic markers for resistance to mastitis. This article presents a systematic integration of complex biological interactions of 226 mammary gland genes to uncover underlying regulatory networks. Data were collected from various databases after having an exhaustive literature study. Network, functional and pathway analysis of the mammary gland genes were performed to find mastitis resistan...
Mohsan Ullah Goraya1,2, Liaqat Ali1,2 and Iqra Younis3
...igger the translation of inflammatory cytokine and chemokines leading to establishment of an antiviral state of the host. In this review, we discuss the recent understanding in host responses to avian viral infection and their impact in health and disease. ...
Rehana Shahida1, Tasnim Farasat1, Shagufta Naz1,* and Shahjahan2
...tify the relationship of inflammatory cytokines with insulin resistance and the molecular mechanisms involved in the interaction of atherosclerosis and hyperglycemia within the context of chosen pro atherogenic parameters including plasma glucose level, serum levels of insulin, IL-6, and TNF-α. Serum level of thrombomodulin was assessed as a measure of vascular damage. Different demographic parameters as age, BMI, waist /hip ratio, B.P., personal history...
Aqsa Gulzar1, Tariq Mahmud1,*, Rubina Munir2 and Asma Anjum3
... anti-cancerous and anti-inflammatory potential of two novel Schiff bases was carried out by MTT - colorimetric protocol on HeLa cells (cervical disease) and Luminol-improved chemiluminescence assay, respectively. The novel Schiff bases 4a and 4b have been synthesized by the reaction of 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide with 3-nitro and 4-nitrobenzaldehyde. Characterization of the synthesized compounds was done...
Niamatullah Kakar, Farhat Abbas, Muhammad Shafee and Tauseef Asmat*
...ved in acute and chronic inflammatory disease. PCR proved to be more sensitive compared to the sputum smears or culture based tuberculosis diagnosis.
... 
Riffat Mehboob1*, Shahida Perveen2, Naseer Ahmed3
...rstand the prevalence of inflammatory lesions, benign neoplasms and their age-wise comparison.
Methodology: The study was carried out at Pathology Department, King Edward Medical University, Lahore. Data of 368 cases of BBD during a time span of 3 years (2011-2014) was obtained retrospectively.
Results: There were 190 patients of fibroadenoma (FA), 81 of fibrocystic disease (FCD), 64 of breast abscess (BA), 12 of gra...
Farhat Ijaz1, Rana Khurram Aftab2*, Samia Jawed3
...t in increased levels of inflammatory markers such as C-reactive protein (CRP), interleukins 6 (1L-6) and tumor necrosis factor alpha (TNF-α). Relation of TNF-α with obesity induced IR and T2DM is unclear as results obtained from different studies are very controversial.
Objective: This study was designed to compare TNF-α levels and insulin resistance in obese and non-obese type 2 diabetics.
Methodology: ...
Xiaojie Ding, Xiling Sun, Zuien Wang, Qiusheng Zheng, Xiaofei Yu, Wenjin Hao, Kejun Wang, Wenjuan Xu and Zhengping Dong*
...0.05), and alleviate the inflammatory reaction and accumulation of bacterial endotoxins; (3) Wumei Pill could reduce the transcriptional level of TLR4/9mRNA, to decrease TLR4/9 protein synthesis and expression. So we concluded that Wumei Pill probably reduce the release of pro-inflammatory cytokines and the bacterial endotoxins by blocking the transmission of TLR4/9-NF-kB signaling pathway so that Wumei Pill has a significan...
Ashraf M. Mounir, A.N. El shahat* and A.M. Abdul Azeem
...esin that possesses anti-inflammatory and antioxidant activity. Gamma-irradiation is used for decontamination of Boswellia tears to achieve satisfactory microbiological quality and public health safety. Hence, examining the effect of gamma-irradiation on the contents of Boswellia oleo-gum resin and also investigating the role of gamma-irradiate frankincense aqueous extract (GFAE) against ISO-induced MI in rats were the two aims of this study. The...
Tünay Kontaş Aşkar1,*, Şinasi Aşkar1, Olga Büyükleblebici2 and Murat Güzel3
...the oxidative stress and inflammatory changes in naturally occurring canine visceral leishmaniasis (CVL). A total of 30 dogs, comprising 10 clinically healthy and 20 dogs with leishmaniasis were enrolled in this study. The diagnosis of canine visceral leishmaniasis was performed by the immune fluorescence antibody test with antibody titter ≥1:128 and lymph node smear examination. In blood samples of dogs with visceral leishmaniasis, levels of malondialdehyd...
Tasleem Akhtar, Nadeem Sheikh*
Induction of acute phase in response to tacrolimus induced hepatotoxicity
...fy;"> Activation of inflammatory pathways may contribute to the beginning and progression of many complications in the body. Current study was aimed to evaluate the status of acute phase response and inflammation by examining the alterations in the level of acute phase proteins due to the toxic effect of an immunosuppressive drug (tacrolimus). Aqueous suspension of tacrolimus powder (3 mg/ml) was orally given to four experimental groups of wistar rats. Co...
Nasir Raza Zaidi1, Mian Waheed Ahmad1, Mahesh Gautam1, Riffat Mehboob2*
Risk factors for multiple sclerosis in Pakistani population- A crosssectional study
...ple sclerosis (MS) is an inflammatory disease of the brain and spinal cord where it damages the myelin sheath
protecting the neurons. Many environmental and genetic factors have been associated with MS. The aim of this study
is to identify the possible risk factors that are linked to MS in Pakistani population. This study was conducted in
Department of Radiology, Mayo Hospital Lahore from 2013 to 2014. The first hundred patients who came f...
protecting the neurons. Many environmental and genetic factors have been associated with MS. The aim of this study
is to identify the possible risk factors that are linked to MS in Pakistani population. This study was conducted in
Department of Radiology, Mayo Hospital Lahore from 2013 to 2014. The first hundred patients who came f...
Jian Wang1,*, Zhi Liu2, Sheng Xu2, Mei-Fen Hu2, Xiao-Rui Liu1 and Wen-Jie Cai1
... involve in a variety of inflammatory and immune response. To investigate the effect of hemodialysis on the expression of CXCL8 in serum and its mRNA in neutrophils of the patients with chronic renal failure (CRF). It was used to dynamically observe of Hemodialysis on the concentration of the CXCL8 in serum and the levels of CXCL8 mRNA in neutrophils were respectively measured by ELISA and PCR. The house keeping gene encoding glyceraldehyde-3-phosphate dehydro...
Jie Yang
... several human diseases (inflammatory bowel disease, ST-elevation myocardial infarction, atherosclerosis, rheumatoid arthritis, skin melanoma and renal carcinoma) have been reviewed. Taken together, these results indicate that human PGLYRP1 encodes an innate immunity protein that breaks down the structure of microbial cell wall, plays a role both in antibacterial defenses and several inflammatory diseases.
...
Rıfat Ertekin1*, Mete Ozkurt1, Gokhan Kus2 and Selda Kabadere1
...) is a nonsteroidal anti-inflammatory medicine stimulating apoptosis in cancer cells like pancreas, oesophagus and lungs. This study aims to determine the role of TA in cell viability and apoptosis in glioma cells (T-98G) and androgen-sensitive human prostate cancer cell line (LNCaP). In our study, 1, 5, 10, 25, 50, and 100 μM doses of TA were applied to T-98G and LNCaP cell lines for periods of 24 and 48 h. Subsequent cell vitality was tested with MTT Ates...
Aqsa Pervaiz1*, Rukhshanda Afridi1, Zahra Pervaiz1, Rabia Masood1 and Hira Pervaiz2
...generation of bile duct, inflammatory infiltration, vacuolization, pyknosis, presence of MMCs and necrosis in hepatocytes. It can be concludedthat methylmercury has harmful effects on histology of liver of fish. Therefore, the present work suggests that the exposure to the methylmercury should be prevented to avoid injurious health hazard risks to fish.
...
Sameh S. Tawfik, Ahmed A. Elkady* and Ehab T. Mohamed
...ent antioxidant and anti-inflammatory drug to prevent and/ or ameliorates the hazardous-effects of γ-rays
...
Ahsan Anjum1, Asim Aslam1, Raheela Akhtar1, Tahir Yaqub2, Muti-ur-Rehman Khan1, Rizwana Sultan3, Saba Usman1, Aneela Zameer Durrani4 and Muhammad Usman4*
...Besides, infiltration of inflammatory cells, congestion, hemorrhages, necrosis and other degenerative changes were observed in tissue samples of infected cattle. Significantly higher (P<0.05) micro-pathological lesion scores were given to lungs, kidney and lymph node samples from infected cattle as compared to those of non-infected ones. In conclusion, CBPP, being a major factor affecting cattle production and associated economics, warrants the implementati...
Mingsan Miao*, Hui Zhao, Jiaojiao Jia, Xiaoyan Fang and Yanyan Miao
...biting the expression of inflammatory factors, repairing damaged nerve cells and improving the pathological changes of cerebral ischemia, proposing its therapeutic potential in treating such anomalies in future.
...
Asmaa A. Darwish
...ters in PG and EG. Ovine inflammatory conditions usually result in different clinicopathological changes. Monitoring of them may be useful in improving our therapeutic intervention and enhancing the animal response to treatment. Both of MMP-2 and MMP-9 is a good marker for sheep inflammatory conditions. ...
Asmaa Abdallah Darwish
...ided into control group, inflammatory diseases groups (pneumonic group, arthritic group, enteric group), late pregnant groups (normal late pregnant group, pregnancy toxemia group), postpartum groups (normal postpartum group, endometric group, mastitic group and non-inflammatory postpartum disorders group). Blood samples were collected from all ewes and vitamins concentrations were estimated in all groups. The results of this...
Hui-Ying Chen1,2*, Ping-Chuan Yin1,2, Ya-Nan Lu1,2, Hai-Yun Li1,2*and Yang Shan3
...in is a widely used anti-inflammatory and antithrombotic drug that exhibits chemopreventive anti-tumor properties. Aspirin is considered to be partially mediated by the induction of apoptosis in cells. However, the underlying molecular mechanisms of aspirin in the prevention of cancer are yet to be fully elucidated. In the current study, the GSE115660 microarray dataset was downloaded from the Gene Expression Omnibus database to identify key genes in aspirin-d...
Anurag Sharma*, Naresh Kumar, Geetanjali Singh and Anika Sharma
... anti-carcinogenic, anti-inflammatory, antibacterial, antifungal and galactagogue activity. The commercially available drugs pose health threats and prove detrimental to both human and animal health. The traditional use of herbal preparations suggests that they are safe and effective, however, scientific validation is still required for many of them especially for animal use. The phyto-pharmacological research on these two natural products show a ray of hope f...
Magbolah Salem Helal Alzahrani
...ed with calming and anti-inflammatory properties. The plant’s healing properties come from its flowers, which contain volatile oils including bisabolol, bisabolol oxides A and B, and matricin as well as flavonoids. This study aims to elucidate the possible therapeutic applications of different levels of M. chamomilla on the functional status of liver, in rats injected with carbon tetrachloride (CCl4), a known hepatotoxin. Thirty-six mal...
Ghulam Akbar1*, Ali Ahmad2, Neha Arooj1, Muhammad Anjum Zia1, Aamna Rafique1, Sania Riasat1, Mohsin Raza1, Mahpara Qamar1, Shahneela Nusrat1 and Shakila Hanif1
Critical Update for the Treatment of Anemia by using Advanced Genome Editing Crispr Cas Technology
...chemic heart ailment and inflammatory bowel disorder. However, with the development in generation at genome editing level have made feasible to accurate mutations in human genome. A site oriented specific break in double stranded DNA is induced by CRISPR/Cas9, whereas different oligonucleotides are provided to make accurate DNA template for genome correction. It is of importance to knowledge about types of CRISPR to treat anemia. Cas 9 showed one of best gene ...
Rida Younas1*, Tamseela Mumtaz1, Nabeela Roohi2 and Muhammad Amir Iqbal3
...ation of expressed of proinflammatory cytokine and chemokine as biomarker was obtained in moderate, severe and very severe COPD patients and established their relationship with lung obstruction. Samples were collected between April and August 2017, total 35 COPD patients with lung obstruction (FEV1/FVC< 70) were enrolled as well as age and sex matched healthy subjects were also recruited as control group. Expression of IL-6 and IL-8 in serum samples were ev...
Yuan Xing, Congming Tan, Yan Luo and Wenjun Liu*
...ll;">Asthma is a chronic inflammatory airway disease, characterized by reversible goblet cells, smooth muscle hyperplasia, airflow obstruction, hyperactivity enhanced, ultra-structural remodeling, and airway mucus production. The current experimental study was aimed at scrutinizing quercetin’s inhibitory effect on airway inflammation in mice and its possible mechanism of action. The mice received varying doses of quercetin from 22-30 days (1, 10 and 50 m...
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
...ic acid have potent anti-inflammatory activity. The aim of the current study was to scrutinize the protective effect of caffeic acid against the streptozotocin induced GDM in rats and explores the possible mechanism of action. A total 36 female rats were caged into the male rats for the pregnancy, and 33 female pregnant rats were collected and weight. The female rats were group into following groups and each group contains 6 rats. Once the pregnancy was verifi...
Qiang Tang1 and Qianli Tang2*
...sed (p<0.001), inflammatory factors TNF-α, IL-6 and IL-1β in skin tissue increased (all p<0.001), and expression levels of Ang-1 and Tie-2 proteins in skin tissue decreased (both p<0.001). Compared with model group, thickness of epidermis, dermis and collagen fibers, and expression levels of Ang-1 and Tie-2 proteins in skin tissue in isoliquiritin group increased (all p<0.001), and inf...
Waseem Khalid1, Ali Ikram1*, Muhammad Rehan2, Farukh Adeem Afzal1, Saadia Ambreen1, Marryam Ahmad3, Afifa Aziz1 and Anam Sadiq1
...lon seed, including anti-inflammatory agents, hypoglycemic agent, antimicrobial, anti-genic and antioxidant potential.
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