Oral or Intrauterine N-Acetyl Cysteine Treatment as A Strategy for Improving the Reproductive Efficiency and Antioxidant Capacity of Lactating Cows
Oral or Intrauterine N-Acetyl Cysteine Treatment as A Strategy for Improving the Reproductive Efficiency and Antioxidant Capacity of Lactating Cows
Hamdy Abdala Elnagar1, Wael Mohamed Wafa1*, Abdel-Khalek El-Sayed Abdel-Khalek2
ABSTRACT
This study aimed to determine the influence of N-Acetyl-Cysteine (NAC), as oral, intrauterine (IU) or oral plus IU administration at early postpartum period, on reproductive performance, antioxidant capacity, and health status of lactating cows. This study included 20 Friesian lactating cows (480±22.7 kg LBW, 2-4 parities and 4.5-6 years old). In day 15 postpartum, cows were divided into four groups, 5 cows/group. Cows in the 1st group represented the control group without treatment (G1). In G2, cows were orally treated with 1.2 g NAC/100 kg BW for 7 days, while 100 ml of 2% NAC solution was infused intrauterine for 3 days for each cow in G3. Cows in G4 were received 0.6 g NAC/100 kg BW orally for 7 days and IU infused by 100 ml of 1% NAC solution for three days. Results showed that cows in G4 showed the highest values of RBCs, Hb, PCV, WBCs, lymphocytes, basophils, total antioxidant capacity, SOD, GSH, catalase, and conception rate, and the lowest values of AST and ALT, creatinine, MDA, TNFα, IFN-γ, IL2, IL6, days-open and number of inseminations per conception. In most postpartum days of all groups, serum P4 and E2 concentrations were in association with conception rate. In conclusion, the dual treatment of lactating cows on day 15 postpartum with 0.6 NAC/kg (orally for 7 days) plus 1% NAC (IU infusion for 3 days) may improve the reproductive efficiency, health performance, antioxidant enzymes, and inflammatory reaction during the postpartum period.
Keywords | Antioxidant, Cows, Cytokines, N-acetyl-cysteine, Reproduction
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August 2022
Vol. 10, Iss. 8, Pages 1659-1886
