The Neuroprotective Effect of Curcumin Cumin Against Oxidative Stress Induced by Acrylamide in Male Rats
The Neuroprotective Effect of Curcumin Cumin Against Oxidative Stress Induced by Acrylamide in Male Rats
Estabraq Hayder Khayoon, Ammar Ahmed Abdulwahid*
ABSTRACT
Rats exposed to Acrylamide )ACR( displayed a neurotoxicity and alteration in behaviors. Curcumin (CUR) is useful in reducing behavioral flaws and restoring a normal body systems’ function. The goal of the current study is to evaluate the how the brain effected oxidatively by Acrylamide exposure and the ability of Curcumin to ameliorate the neurotoxicity. For this investigation, thirty mature male albino rats be used, (10/group), the control group (CC), animals were intubated with distilled water for 40 days, Group G1, rats received Acrylamide 5 mg/kg B.W. every day for 40 days by gavage needle, and Group G2, in this group animals got Acrylamide 5 mg/kg B.W. and Curcumin 100 mg/kg B.W. for 40 days by gavage needle as well. At the zero and the end times of the experiment, blood samples were taken using the heart puncture technique after the subjects had been given an intramuscular injection of ketamine and xylazine to induce anesthesia. The findings revealed the exposure of Acrylamide to rats significantly reduced their tendency to gain weight, a marked rise in the concentration of malondialdehyde and decrease levels of Total antioxidant in blood serum and behavioral differences like Acrylamide greatly decreased the struggling and ascending time in the swimming test, dramatically lengthens the time needed to turn an animal’s head 180 degrees during a negative geotaxis test and decreased locomotors activity in the Y maze test. Curcumin’s anti-apoptotic, anti-inflammatory, and antioxidant properties have not been thoroughly examined in neurotoxicity given on by Acrylamide, nevertheless. We investigated whether Curcumin may protect against oxidative stress, apoptosis, and inflammation in neurons brought on by Acrylamide exposure. In conclusion acrylamide alters the neurobehaviors and oxidatively stressed animals .However Curcumin restored these parameters close to control values.
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