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Effect of Sodium Hyaluronate and Betamethasone Injection in Knuckle Articular Cavity on Serum Inflammatory Factors and Metalloproteinase of Knee Osteoarthritis Patients

Effect of Sodium Hyaluronate and Betamethasone Injection in Knuckle Articular Cavity on Serum Inflammatory Factors and Metalloproteinase of Knee Osteoarthritis Patients

Zhaojun Wang1, Yang Zhou2 and Xinghua Song3*

1Pharmacy Department, The Fourth People’s Hospital of Jinan, Jinan, 250031, China
2Pharmacy Department, The First People’s Hospital of Jinan, Jinan, 250011, China
3Orthopaedics, Dongying Hospital of Traditional Chinese Medicine, Dongying, 257055, China
 
* Corresponding author: slyywwh@163.com

ABSTRACT

The aim of this study was to observe the efficacy of injection of sodium hyaluronate combined with betamethasone into knuckle articular cavity in knee osteoarthritis treatment, and to analyze its effect on the prognosis of knee joint function. A total of 120 knee osteoarthritis patients admitted to our hospital from January 2019 to February 2020 were selected as the study subjects and randomly divided into control group and observation group (60 cases each). The control group was given injection of sodium hyaluronate in knuckle articular cavity, and the observation group was further treated with compound betamethasone. Clinical efficacy of the two groups was observed after treatment, the knee joint pain before and after treatment was evaluated using visual analogue scale (VAS), and Lysholm knee function score was given. The patients’ serum interleukin-1β (IL-β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were detected using ELISA method before treatment and 3 months after treatment; incidence of adverse prognostic reactions was compared between the two groups. After treatment, the observation group had 34 markedly effective cases and 21 effective cases, with total effective rate of treatment at 91.67%. The figure was significantly higher compared to 80.00% of the control group, showing statistically significant difference (P<0.05). After treatment, the patients’ VAS score and 20 m walking time were significantly reduced, with Lysholm score increased significantly (P<0.05). The observation group patients’ VAS, Lysholm knee score and 20 m walking time were 3.42±0.60 points, 87.74±10.36 points and 7.16±2.05 s, respectively, which were significantly superior to the control group, showing statistically significant difference (P<0.05). After treatment, the patients’ inflammatory factor level was significantly lower, and matrix metalloproteinases content was also significantly reduced (P<0.05). IL-1β, IL-6 and TNF-α in the observation group were respectively 8.07±3.13 ng/mL, 9.31±6.83 ng/mL and 7.72±1.86 pg/mL, with MMP-3 and MMP-9 contents at 29.42±6.74 and 20.23±5.24, showing significantly superior improvement compared with the control group and indicating statistically significant difference (P<0.05). The incidence of adverse reactions was 3.33% (2/60) in the observation group, which was significantly lower than 15.00% in the control group, and the difference was not statistically significant (P<0.05). To conclude, significant therapeutic effect was observed in KOA patients treated with injection of sodium hyaluronate combined with compound betamethasone in knuckle articular cavity, which can effectively relieve pain and reduce serum inflammatory factors IL-1β, IL-6, TNF-α and matrix metalloproteinase MMP-3, MMP-9 contents, relieve knee arthritic excessive activation and protease degradation, reduce the incidence of adverse reactions, and promote the recovery of prognostic joint function.

 

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Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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