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Clinical Therapy of Shujin Huoxue Tablet Combined with Sodium Hyaluronate on Inflammatory Factors of Synovial Fluid (IL-6, TNF-α) in the Treatment of Knee Osteoarthritis: Clinical Trial Study

Clinical Therapy of Shujin Huoxue Tablet Combined with Sodium Hyaluronate on Inflammatory Factors of Synovial Fluid (IL-6, TNF-α) in the Treatment of Knee Osteoarthritis: Clinical Trial Study

Guangyu Wang, Xu Tian, Lintao Liu, Junyang Liu, Bo Zhang and Jingming Dong*

Trauma Upper Limb Department, Tianjin Hospital, Tianjin, 300211, China

*      Corresponding author: academicres22@yahoo.com

ABSTRACT

Sodium hyaluronate are used to reduce pain and improve function in patients with knee osteoarthritis (KOA) and in traditional Chinese medicine, Shujin Huoxue Tablets (SJHXT) is known to be a useful medicine for KOA. The aim of this study was to investigate the effects of SJHXT combined with sodium hyaluronate on synovial inflammation in a patients with KOA. A total of 180 patients with knee osteoarthritis who were treated in our hospital were enrolled as the study subjects who were divided into study group and reference group, each with 90 cases. The reference group received sodium hyaluronate injection treatment, while the study group was given SJHXT combined with sodium hyaluronate. The therapeutic effects were compared between the two groups. Comparison of Lysholm knee score scale, WOMAC score, and joint VAS score between the two groups showed that the study group had a significant advantage over the reference group after treatment, p<0.05. Comparison of synovial fluid inflammatory factors before and after treatment between the two groups indicated more obvious improvement in the study group than in the reference group, p<0.05. Comparison of overall treatment efficiency of the two groups showed significantly higher efficiency in the study group than in the reference group, p<0.05. To conclude SJHXT combined with sodium hyaluronate can produce good therapeutic effects for patients with knee osteoarthritis, which can positively affect the synovial fluid inflammatory factors so that effectiveness of adjuvant treatment can be improved.

 

 

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Pakistan Journal of Zoology

August

Vol. 53, Iss. 4, Pages 1201-1601

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