Expression of Somatostatin Type-2 Receptors in Mouse Dorsal Root Ganglion at Early Stage of Pain Models: Evidence for the Inhibitory Role of Somatostatin in Pain
Expression of Somatostatin Type-2 Receptors in Mouse Dorsal Root Ganglion at Early Stage of Pain Models: Evidence for the Inhibitory Role of Somatostatin in Pain
Qiong Xiang1, Jing-Jing Li1, Qian Zhang1,3, Rong-Bo Tian1 and Xian-Hui Li1,2*
ABSTRACT
Our previous study has indicated that Somatostatin type-2 receptor (SSTR2) antibody enhances mechanical hyperalgesia in dorsal root ganglion neurons (DRGs) based on Pinch-nerve injury painful model. However, more details on the role of SSTR2 involved should have been clearly elucidated. Here in this study, we focused on the early phase of painful process; detected the painful hyperalgesia and allodynia induced by Pinch-nerve injury firstly; and then we analysed the expression of SSTR2 protein in DRGs after injecting Carrageenan, the inflammation-induced reagent into the mouse left-hind paw(Ipsilateral-side). Compared with the SSTR2 in normal right -hind paw(contralateral-side) DRGs. The variation of SSTR2 protein expression is fast, because about 15 min after injection the significant up-regulated expression of the SSTR2 proteins are found in inflammatory DRG neurons compared to that of in control DRG neurons. The process is also time-dependent, because no difference is seen after one-day injection. Meanwhile, we also analysed the SSTR2 expression in other types of painful models (i.e., DR and SNI); Thus, our data suggested that changes of SSTR2 expression at the short time painful stage which has influenced in the painful signal transduction maintain and may be the clues and evidence for Somatostatin inhibits neuronpathic pain based on our previous work.
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