Fecal Calprotectin Concentrations and Other Indicators in Dogs with Idiopathic Inflammatory Bowel Disease
Fecal Calprotectin Concentrations and Other Indicators in Dogs with Idiopathic Inflammatory Bowel Disease
Heba El-Zahar*, Zeinab Abd El-Rahman, Abbas El-Naggar
ABSTRACT
Inflammatory bowel disease (IBD) is a disease characterized by chronic gastrointestinal inflammation. Due to the continuous rise in incidence, simple and cost-effective methods of diagnostic and clinical assessment are urgently required. The goal of this study was to look at the hematobiochemical alterations in association with the evaluation of C-reactive proteins (CRP), haptoglobin and fecal calprotectin concentration as prognostic markers in dogs with IBD. After a detailed clinical, laboratory and ultrasonographic examination 21 IBD dogs with symptoms of chronic gastrointestinal diseases were chosen for the study. In addition to 11 healthy dogs served as control group. In comparison to controls, hematological analysis revealed significant variations (p<0.05) in total leukocyte count, hemoglobin, and mean platelet volume and significant variation (p<0.01) in neutrophils and platelet count. The biochemical analysis revealed a significant rise in serum activity of aspartate aminotransferase (p<0.05), and blood urea nitrogen, blood creatinine, lipase and alkaline phosphatase (p<0.01) in IBD dogs. The mean values of IBD-related biomarkers (CRP, haptoglobin, and fecal calprotectin concentrations) increased significantly (p<0.05 or p<0.01) compared to controls. CRP, haptoglobin concentrations, and fecal calprotectin were found to have a strong positive correlation. Furthermore, blood enzymes, glucose and electrolytes were significantly correlated with CRP as an IBD-related biomarker. It is concluded that, hematological indices such as total leukocyte count, neutrophils and platelets count may consider non-invasive hematological markers in IBD dogs as they were increased significantly. In addition, CRP, haptoglobin, and fecal calprotectin were also discovered to be powerful IBD biomarkers and might be used as surrogate measures of disease severity in dogs with IBD.
Keywords | IBD, Fecal calprotectin, CRP, Haptoglobin
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