Comparative Evaluation of RF and Anti-CCP Tests for Rheumatoid Arthritis Diagnosis: Insights from a Pakistani Population
Comparative Evaluation of RF and Anti-CCP Tests for Rheumatoid Arthritis Diagnosis: Insights from a Pakistani Population
Muhammad Waqas*, Razia Bashir and Muhammad Arshad
ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that principally affects joints. Various diagnostic techniques are in use to detect RA based on the presence of auto-antibodies in patients’ blood like rheumatoid factor and anti-cyclic citrullinated peptides. We aimed to detect RF and anti-CCP antibodies for diagnostic evaluation of RA. RF was done by the latex agglutination method while anti-CCP test was performed on Abbot AxSYM system using micro-particle enzyme immunoassay method. The analysis showed that RF test is more prevalent than anti-CCP to determine whether an individual has RA or not. In the present study RA is also found to be associated with age of the patients. To conclude RA is an age-related disorder that can be detected earlier by the presence of RF autoantibodies as compared to anti-CCP. These findings can be helpful for the clinical diagnosis of RA.
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