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Curative Effect of Glucocorticoid Combined with Respiratory Stimulant on AECOPD Patients

Curative Effect of Glucocorticoid Combined with Respiratory Stimulant on AECOPD Patients

Mingqing Wang1 and Xiaojuan Chen2,*

1Respriratory Medicine Ward, Hangzhou Fuyang Hospital of Traditional Chinese Medicine, Hangzhou, 311400, China
2General Department, Fuyang District Changkou Community Health Service Center, Hangzhou, 310000, China
* Corresponding author:


As there is a high rate of the treatment failure in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and many studies have tried to specify an effective treatment. Objective of this study was to observe and analyze the therapeutic effect of glucocorticoid combined with respiratory stimulant on patients with AECOPD along with the optimal nursing care required for these patients. Also, tumor necrosis factor-alpha (TNF-a) was assessed as an inflammatory factor to see the response to treatment. In this study, 180 AECOPD patients who had been treated in our hospital were enrolled as research objects, who were given routine respiratory stimulant therapy regimen and intravenous methylprednisolone. According to the dosage of glucocorticoid methylprednisolone, the patients were divided into three groups, each containing 60 patients. The changes of arterial blood gas parameters including pH value, oxygen partial pressure (PaO2) and carbon dioxide partial pressure (PaCO2) were compared. We found that respiratory stimulant combined with different doses of glucocorticoid methylprednisolone positively improve the pH value of patients with acidosis, increase the partial pressure of oxygen and lower the partial pressure of carbon dioxide (P<0.05 in all three groups). Methylprednisolone at 40mg every 12 h proved better than other doses (p<0.05). The average length of stay was (12.5±3.0) days, the complication rate was 6.67%, and the overall nursing satisfaction was 97.22%, which shows that this is an auxiliary way to improve the treatment effect of patients. 

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Pakistan Journal of Zoology


Vol. 54, Iss. 6, Pages 2501-3000


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