Humam T. Hadi1*, Orooba M. S. Ibrahim2
ABSTRACT
Psoriasis is a systemic inflammatory autoimmune disease characterized by skin abrasions, with the plaque subtype accounting for around 85% of all cases. Green chemistry emerged as a realistic and simple alternative to more difficult chemical synthesis techniques for generating gold nanoparticles. This study evaluated the potential of Syzygium aromaticum gold nanoparticles (SaAuNPs) in treating psoriasis in mice. The study had two parts. The first part involved the extraction of clove oil and the synthesis of SaAuNPs using a green synthesis method. The second part involved the induction of psoriasis in mice using 5% imiquimod cream, followed by topical application of different concentrations of SaAuNPs, clove oil, and salicylic acid. The second part evaluated the effectiveness of SaAuNPs in reducing psoriasis symptoms in mice. The findings showed that SaAuNPs had a significant (P≤0.05) anti-inflammatory effect, with the groups treated with 0.003% and 0.005% SaAuNPs showing a significant reduction in psoriasis symptoms. The physicochemical properties of SaAuNPs were characterized using numerous techniques, including UV-visible spectroscopy, Zeta potential measurement, particle size analysis, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The SaAuNPs showed a UV-visible spectrum at 562 nm, a zeta potential of 90mV, and a particle size of 48nm. The XRD revealed a crystalline nature of the particles, and the SEM showed regular spherical nanoparticles. The study also showed that clove oil and salicylic acid had similar results but to a lesser extent and with non-significant findings. The outcomes suggest that SaAuNPs could be an encouraging alternative approach for the treatment of psoriasis, which can be further explored in future studies.
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