Curcumin Phytosome as an Anti- inflammatory and Hypolipidemic in Nano-Silicon Treated Female Rats
Curcumin Phytosome as an Anti- inflammatory and Hypolipidemic in Nano-Silicon Treated Female Rats
Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2
ABSTRACT
The oral toxicity of silicon dioxide nanoparticles (SiO2NPs) effect the immune system and lipid profile, Curcumin Phytosome nanoparticles (CPNPs) possess several biological activities including anti-inflammatory, and hypolipidemic effects. We determined dyslipidemia and inflammatory state induced by exposure to silicon dioxide nanoparticles (SiO2NPs) in female rats could be ameliorated by the administration of Curcumin Phytosome nanoparticles (CPNPs). Curcumin Phytosome NPs’ impact on dyslipidemia and inflammatory state in SiO2NPa-exposed female rats was investigated. Approximately 32 female rats were divided into four groups as follows: T1: was administered oral 200 mg/kg of SiO2NPs, T2: received oral SiO2NPs and 100mg/kg of curcumin phytosome, and T3: was administered oral 100 mg/kg of curcumin phytosome. Blood samples were collected from anesthetized rats through cardiac puncture by terminating the experiment. The samples were analyzed for total cholesterol (TC), triacylglycerols (TAG), high-density lipoprotein (HDL)-c, low-density lipoprotein (LDL)-c, very low-density lipoprotein (VLDL)-c concentrations, tumor necrosis factor-alpha (TNF-), and interleukin 10 (IL-10) concentrations. The results revealed the development of signs of incitement such as increased TC and reduced IL-10, decreased HDL-C, and increased TC, TAG, VLDL-C, and LDL-C, along with an increase in inflammatory markers. CPNPs reduced dyslipidemia and inflammation in female rats. We implied the protective impact of CPNPs, which may be seen in the anti-inflammatory and hypolipidemic, against the deleterious effects of silica.
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